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Anti-PIGR (rabbit polyclonal)

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货号：ABS695

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R, Chp WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number ABS95
Description Anti-NDK A Antibody
Alternate Names
  • Nucleoside diphosphate kinase A
  • NDK A
  • NDP kinase A
  • Granzyme A-activated Dnase
  • GAAD
  • Metastasis inhibition factor nm23
  • Tumor metastatic process-associated protein
  • nm23-H1
Background Information NME1/NDK A is a metastasis-suppressor protein that has been found to be down-regulated in human lung cancer cells. Polymorphisms in NDK A have shown a significant association with propensity and severity of lung cancer, breast cancer and other forms of human cancer. NDK A is known as a tumor metastasis suppressor that works on a wide range of tumors. Recently, NDK A has also been found to regulate subcellular trafficking of annexin IV and EF-1Bα.
References
Product Information
Format Affinity Purified
Control
  • MCF7 cell lysate
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-NDK A Antibody is an antibody against NDK A for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to human NDK A.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Species Reactivity
  • Human
  • Mouse
  • Rat
  • Chimpanzee
Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat. Predicted to react with Chimpanzee based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq].
Gene Symbol
  • NME1
  • NDPKA
  • NM23
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.

CATALYTIC ACTIVITY: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

COFACTOR: Magnesium.

ENZYME REGULATION: Autophosphorylation at His-118 increases serine/threonine protein kinase activity of the enzyme. Interaction with the SET complex inhibits exonuclease activity.

SUBUNIT STRUCTURE: Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with SET and PRUNE.

SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note: Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.

TISSUE SPECIFICTY: Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation. Isoform 3 is ubiquitously expressed. MISCELLANEOUS: The role of this protein in tumor development and progression is uncertain. This protein is found in reduced amount in some tumor cells of high metastatic potential. However, increased NME1 levels correlate with aggressive tumor features in neuroblastoma. May have distinct if not opposite roles in different tumors.

SEQUENCE SIMILARITIES: Belongs to the NDK family.

SEQUENCE CAUTION: The sequence CAA35621.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
Molecular Weight ~17 kDa observed. Uniprot describes 3 isoforms produced by alternative splicing; two of which have molecular weights of 17 and 19 kDa respectively.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in MCF7 cell lysate.

Western Blot Analysis: 0.05 µg/mL of this antibody detected NDK A on 10 µg of MCF7 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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