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Qiagen 凯杰 Biosharp Omega

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Anti-PLA2G7 (rabbit polyclonal)

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货号：ABS694

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, R, M, Chp, Rhesus Macaque IH(P) Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number ABS94
Description Anti-MLK1 Antibody
Alternate Names
  • Mitogen-activated protein kinase kinase kinase 9
  • Mixed lineage kinase 1
Background Information MLK1 (MAP3K9) is a serine–threonine kinase of the Mixed-Lineage Kinase (MLK) family capable of activating the c-Jun N-terminal Kinase (JNK)/Mitogen-Activated Protein Kinase (MAPK) pathway and regulating the other two prinicpal MAPK cascades, p38 and extracellular signal regulated kinase (ERK). Immunoblots and mass spectrometry show MLK is threonine phosphorylated in or near the activation loop. Studies show that MLKs play a role in the TGF-beta1-induced cell death mechanism.
References
Product Information
Format Affinity Purified
Control
  • Colorectal adenocarcinoma tissue
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-MLK1 Antibody detects level of MLK1 & has been published & validated for use in IH(P).
Key Applications
  • Immunohistochemistry (Paraffin)
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to human MLK1.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Species Reactivity
  • Human
  • Rat
  • Mouse
  • Chimpanzee
  • Rhesus Macaque
Species Reactivity Note Demonstrated to react with Human.
Predicted to react with Rat, Mouse, Chimpanzee, and Rhesus Macaque based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • MAP3K9
  • MLK1
  • PRKE1
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Activates the JUN N-terminal pathway.

CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

COFACTOR: Magnesium.

ENZYME REGULATION: Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation (By similarity).

SUBUNIT STRUCTURE: Homodimer (By similarity).

TISSUE SPECIFICITY: Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.

PTM: Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site.

SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

Contains 1 protein kinase domain.

Contains 1 SH3 domain.

SEQUENCE CAUTION: The sequence AAI11408.1 differs from that shown. Reason: Erroneous initiation.
Molecular Weight 121 kDa (isoform 1), 123 kDa (isoform 2) calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Immunohistochemistry in colorectal adenocarcinoma tissue.

Immunohistochemistry Analysis: A 1:300 dilution of this antibody detected MLK1 in colorectal adenocarcinoma tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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