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Anti-AP-2g, clone 6E4/4 (mouse monoclonal IgG1)

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货号：05-909

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M WB, IHC M Purified Monoclonal Antibody
Description
Catalogue Number 05-909
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-AP-2γ Antibody, clone 6E4/4
References
Product Information
Format Purified
Applications
Application Detect AP-2γ also known as Transcription Factor AP-2 gamma with Anti-AP-2γ Antibody, clone 6E4/4 (Mouse Monoclonal Antibody), that has been demonstrated to work in WB & IHC.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Biological Information
Immunogen Bacterially expressed AP-2 protein
Clone clone 6E4/4
Host Mouse
Specificity AP-2γ. Reported to not cross-react with AP-2α or AP-2β.
Isotype IgG
Species Reactivity
  • Human
  • Mouse
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube.
Gene Symbol
  • TFAP2C
  • AP2-GAMMA
  • TFAP2G
  • hAP-2g
  • AP2-gamma
  • ERF1
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q92754 # Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC.
SIZE: 450 amino acids; 49177 Da
SUBUNIT: Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity). Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I.
SUBCELLULAR LOCATION: Nucleus (Probable).
DOMAIN:SwissProt: Q92754 The WW-binding motif mediates interaction with WWOX.
PTM: Sumoylated on Lys-10; which inhibits transcriptional activity.
SIMILARITY: Belongs to the AP-2 family.
Molecular Weight Mr 50kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoblot on nuclear extracts from HeLa cells
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions stable 2 years at -20°C from date of shipment
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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