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Anti-RNA Polymerase II, CTD, clone 8WG16

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货号：05-952

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M, H WB M Purified Monoclonal Antibody
Description
Catalogue Number 05-1952
Description Anti-SETDB2 Antibody, clone 5B7.2
Alternate Names
  • SET domain, bifurcated 2
  • chromosome 13 open reading frame 4
  • chronic lymphocytic leukemia deletion region 8
  • Lysine N-methyltransferase 1F
  • histone-lysine N-methyltransferase SETDB2
  • Chronic lymphocytic leukemia deletion region gene 8 protein
  • SET domain bifurcated 2
Background Information SET domain bifurcated 2 (SETDB2), also known as Histone-lysine N-methyltransferase SETDB2 is a ubiquitous, nuclear protein belonging to the histone-lysine methyltransferase family and is comprised of a MBD (Methyl-CpG-binding) domain, a pre-SET domain, and a SET domain. Data suggests that SETDB2 is a methyltransferase with specific activity against histones. Studies also suggest that it may be a key regulatory component in the development of dorsal organizer and left-right asymmetry during early embryonic development by downregulating fibroblast growth factor 8. Although expression of the protein is considered ubiquitous, high levels have been reported in heart, ovary and testis tissues.
References
Product Information
Format Purified
Control
  • A431 cell lysate
Presentation Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Applications
Application Use Anti-SETDB2 Antibody, clone 5B7.2 (mouse monoclonal antibody) validated in WB to detect SETDB2 also known as SET domain bifurcated 2, chronic lymphocytic leukemia deletion region 8, histone-lysine N-methyltransferase SETDB2.
Key Applications
  • Western Blotting
Biological Information
Immunogen Recombinant protein corresponding to human SETDB2.
Clone 5B7.2
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Isotype IgMκ
Species Reactivity
  • Mouse
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).[supplied by OMIM].
Gene Symbol
  • SETDB2
  • CLLD8
  • KMT1F
  • CLLL8
Purification Method Ion Exchange
UniProt Number
UniProt Summary FUNCTION: Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.

CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

SUBCELLULAR LOCATION: Nucleus. Chromosome Probable

TISSUE SPECIFICTY: Ubiquitous. Highest expression in heart, testis and ovary.

SEQUENCE SIMILARITIES: Belongs to the histone-lysine methyltransferase family.

Contains 1 MBD (methyl-CpG-binding) domain.

Contains 1 pre-SET domain.

Contains 1 SET domain.

SEQUENCE CAUTION: The sequence CAH56265.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

The sequence CAI10818.2 differs from that shown. Reason: Erroneous gene model prediction.
Molecular Weight ~ 80 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in A431 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected SETDB2 on 10 µg of A431 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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