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PI 3-Kinase (Class II) HTRF Assay - 5-plate kit (DU)

市场价：
86.00
促销价：
¥0.00

货号：33-039

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 33-039
Brand Family Upstate
Trade Name
  • HTRF
  • Upstate
Description PI 3-Kinase Class II HTRF Assay
References
Product Information
Components
  • Reaction Buffer (4X)
  • DM A Detection Reagent
  • DM C Detection Reagent
  • DM D Detection Reagent
  • Phosphatidylinositol (1mM)
  • Phosphatidylserine (1mM)
  • Stop Reagent C
Detection method HTRF
Applications
Application Five-plate kit (1920 wells) of reagents for performing PI 3-Kinase (Class II) 4-step HTRF assays. Suitable for the following Kinases: PI3KC2α, PI3KC2β & PI3KC2γ.
Key Applications
  • Kinase Assay
Biological Information
Species Reactivity
  • Human
  • Mouse
Analytes Available
  • PI 3-Kinase Class II
Entrez Gene Number
Entrez Gene Summary Phosphoinositide 3-kinase-C2 proteins generate phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. This protein belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner.
Gene Symbol
  • PI3KC2α
  • PI3KC2β
  • PI3KC2γ
Target Sub-Family PI3K/PI4K
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 12 months at -70°C
Packaging Information
Material Size 1920 wells
Material Package Kit capacity: 1920 wells
Transport Information
Supplemental Information
Specifications

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