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ANTI-IGFB-3

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货号：06-108

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H IP, WB Rb Serum Polyclonal Antibody
Description
Catalogue Number 06-108
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-IGFBP-3 Antibody
References
Product Information
Format Serum
Presentation Lyophilized
Applications
Application This Anti-IGFBP-3 Antibody is validated for use in IP, WB for the detection of IGFBP-3.
Key Applications
  • Immunoprecipitation
  • Western Blotting
Biological Information
Immunogen human recombinant IGFBP-3
Host Rabbit
Specificity IGFBP-3
Isotype IgG
Species Reactivity
  • Human
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Gene Symbol
  • IGFBP3
  • BP-53
  • IBP3
  • IGFBP-3
Purification Method Antiserum
UniProt Number
UniProt Summary FUNCTION: SwissProt: P17936 # IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
SIZE: 291 amino acids; 31674 Da
SUBUNIT: Interacts with XLKD1 (By similarity). Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed by most tissues.
DEVELOPMENTAL STAGE: IGFBP3 levels are higher during extrauterine life and peak during puberty.
DOMAIN: SwissProt: P17936 The thyroglobulin type-1 domain mediates interaction with HN.
SIMILARITY: Contains 1 IGFBP N-terminal domain. & Contains 1 thyroglobulin type-1 domain.
Molecular Weight 40-47kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoblot on IGFBP-3 (Catalog #12-131)
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at 4°C
Packaging Information
Material Size 200 µL
Transport Information
Supplemental Information
Specifications

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