Anti-FoxP2 (rabbit polyclonal)

Species Reactivity	Key Applications	Host	Format	Antibody Type
M, Rb, H	WB, IHC	Rb	Serum	Polyclonal Antibody

Species Reactivity

Key Applications

Host

Format

Antibody Type

M, Rb, H

WB, IHC

Serum

Polyclonal Antibody

Description
Catalogue Number	ABE73
Description	Anti-FoxP2 Antibody
Alternate Names	forkhead box P2 trinucleotide repeat containing 10 CAG repeat protein 44 forkhead/winged-helix transcription factor Trinucleotide repeat-containing gene 10 protein speech and language disorder 1
Background Information	Forkhead box protein P2 (FoxP2) is a multidomain transcriptional repressor that belongs to the Fox family of proteins. The FoxP2 protein contains a forkhead-box DNA-binding domain, characteristic of the FOX group of transcription factors. In addition, this protein contains a polyglutamine tract, as well as zinc finger and leucine zipper motifs. In order for FoxP2 to bind DNA, it forms homodimers and heterodimers with FoxP1 and FoxP4. The forkhead box family of proteins play an important role in immune response, organ development and the development of cancer. Functional studies in vertebrates suggest this with this gene plays a role in the modulation neural plasticity. In line with these findings, mutations of FoxP2 in humans have been linked to speech and language disorders.

Description

Catalogue Number

ABE73

Description

Anti-FoxP2 Antibody

Alternate Names

forkhead box P2
trinucleotide repeat containing 10
CAG repeat protein 44
forkhead/winged-helix transcription factor
Trinucleotide repeat-containing gene 10 protein
speech and language disorder 1

Background Information

Forkhead box protein P2 (FoxP2) is a multidomain transcriptional repressor that belongs to the Fox family of proteins. The FoxP2 protein contains a forkhead-box DNA-binding domain, characteristic of the FOX group of transcription factors. In addition, this protein contains a polyglutamine tract, as well as zinc finger and leucine zipper motifs. In order for FoxP2 to bind DNA, it forms homodimers and heterodimers with FoxP1 and FoxP4.
The forkhead box family of proteins play an important role in immune response, organ development and the development of cancer. Functional studies in vertebrates suggest this with this gene plays a role in the modulation neural plasticity. In line with these findings, mutations of FoxP2 in humans have been linked to speech and language disorders.

Product Information
Format	Serum
Control	RAW264.7 cell lysate
Presentation	Unpurified rabbit polyclonal serum with 0.05% sodium azide.

Product Information

Format

Serum

Control

RAW264.7 cell lysate

Presentation

Unpurified rabbit polyclonal serum with 0.05% sodium azide.

Applications
Application	Anti-FoxP2 Antibody is a Rabbit Polyclonal Antibody for detection of FoxP2 also known as forkhead box P2, trinucleotide repeat containing 10 & has been validated in WB & IHC.
Key Applications	Western Blotting Immunohistochemistry
Application Notes	Western Blot Analysis: 1:1,000 dilution from a representative lot detected FoxP2 in 10 µg of L6, NIH/3T3, mouse brain, rat brain, and human brain lysates. Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in IH. (Lu, M.M., et al. (2002). Mechanisms of Development 119S:S197–S202.)

Applications

Application

Anti-FoxP2 Antibody is a Rabbit Polyclonal Antibody for detection of FoxP2 also known as forkhead box P2, trinucleotide repeat containing 10 & has been validated in WB & IHC.

Key Applications

Western Blotting
Immunohistochemistry

Application Notes

Western Blot Analysis: 1:1,000 dilution from a representative lot detected FoxP2 in 10 µg of L6, NIH/3T3, mouse brain, rat brain, and human brain lysates.

Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in IH. (Lu, M.M., et al. (2002). Mechanisms of Development 119S:S197–S202.)

Biological Information
Immunogen	GST-tagged recombinant protein corresponding to mouse FoxP2.
Epitope	Unknown
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Rabbit
Specificity	This antibody recognizes FoxP2.
Isotype	IgG
Species Reactivity	Mouse Rabbit Human
Species Reactivity Note	Demonstrated to react with human, mouse, and rabbit.
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NP_444472
Gene Symbol	CAGH44 TNRC10 SPCH1
Purification Method	Unpurified
UniProt Number	P58463
UniProt Summary	FUNCTION: Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. SUBUNIT STRUCTURE: Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. SUBCELLULAR LOCATION: Nucleus Probable. TISSUE SPECIFICITY: Highest expression in lung. Lower expression in spleen, skeletal muscle, brain, kidney and small intestine. DEVELOPMENTAL STAGE: Expressed in developing lung, neural, intestinal and cardiovascular tissues. Expressed at a high level in the distal airway epithelium and at a low level in the proximal airway epithelium at 12.5 dpc, and restricted to the distal airway epithelium by 14.5 dpc. In the spinal cord, at 12.5 dpc, expressed in a subset of interneurons dorsal to motor neurons. At 16.5 dpc, expression in the brain is observed in the inner intermediate zone of the neopallial cortex and in the developing cerebral hemispheres. In the gastrointestinal system, at 12.5 expressed in the outer mesodermal layer and in the intestinal epithelium. By 16.5 dpc, expression is restricted to the outer longitudinal muscle layer of the intestine and stomach. In the cardiovascular system, at 14.5 dpc, expressed in the outflow tract region of the developing heart. By 16.5 dpc, observed in the outflow tract and atrium, but not in the ventricles. DOMAIN: The leucine-zipper is required for dimerization and transcriptional repression. SEQUENCE SIMILARITIES: Contains 1 C2H2-type zinc finger. Contains 1 fork-head DNA-binding domain.
Molecular Weight	80 and 77 kDa Observed. Alternative splicing can result in cell type dependent isoforms.

Biological Information

Immunogen

GST-tagged recombinant protein corresponding to mouse FoxP2.

Epitope

Unknown

Concentration

Please refer to the Certificate of Analysis for the lot-specific concentration.

Host

Rabbit

Specificity

This antibody recognizes FoxP2.

Isotype

IgG

Species Reactivity

Mouse
Rabbit
Human

Species Reactivity Note

Demonstrated to react with human, mouse, and rabbit.

Antibody Type

Polyclonal Antibody

Entrez Gene Number

NP_444472

Gene Symbol

CAGH44
TNRC10
SPCH1

Purification Method

Unpurified

UniProt Number

P58463

UniProt Summary

FUNCTION: Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential.

SUBUNIT STRUCTURE: Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1.

SUBCELLULAR LOCATION: Nucleus Probable.

TISSUE SPECIFICITY: Highest expression in lung. Lower expression in spleen, skeletal muscle, brain, kidney and small intestine.

DEVELOPMENTAL STAGE: Expressed in developing lung, neural, intestinal and cardiovascular tissues. Expressed at a high level in the distal airway epithelium and at a low level in the proximal airway epithelium at 12.5 dpc, and restricted to the distal airway epithelium by 14.5 dpc. In the spinal cord, at 12.5 dpc, expressed in a subset of interneurons dorsal to motor neurons. At 16.5 dpc, expression in the brain is observed in the inner intermediate zone of the neopallial cortex and in the developing cerebral hemispheres. In the gastrointestinal system, at 12.5 expressed in the outer mesodermal layer and in the intestinal epithelium. By 16.5 dpc, expression is restricted to the outer longitudinal muscle layer of the intestine and stomach. In the cardiovascular system, at 14.5 dpc, expressed in the outflow tract region of the developing heart. By 16.5 dpc, observed in the outflow tract and atrium, but not in the ventricles.

DOMAIN: The leucine-zipper is required for dimerization and transcriptional repression.

SEQUENCE SIMILARITIES: Contains 1 C2H2-type zinc finger.

Contains 1 fork-head DNA-binding domain.

Molecular Weight

80 and 77 kDa Observed. Alternative splicing can result in cell type dependent isoforms.

Product Usage Statements
Quality Assurance	Evaluated by Western Blot in RAW264.7 cell lysate. Western Blot Analysis: 1:1,000 dilution of this antibody detected FoxP2 on 10 µg of RAW264.7 cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Product Usage Statements

Quality Assurance

Evaluated by Western Blot in RAW264.7 cell lysate.

Western Blot Analysis: 1:1,000 dilution of this antibody detected FoxP2 on 10 µg of RAW264.7 cell lysate.

Usage Statement

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Storage and Shipping Information

Storage Conditions

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Packaging Information
Material Size	100 µL

Packaging Information

Material Size

100 µL

实验耗材

分子生物学试剂

蛋白与免疫学

生化试剂

细胞及检测试剂

色谱及层析

仪器设备

实验服务

办公用品

Anti-FoxP2 (rabbit polyclonal)

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