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Anti-PDX1 (rabbit polyclonal)

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货号：06-1379

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M, H WB, IHC Rb Serum Polyclonal Antibody
Description
Catalogue Number 06-1379
Description Anti-PDX1 (rabbit) Antibody
Alternate Names
  • pancreatic and duodenal homeobox 1
  • pancreatic-duodenal homeobox factor 1
  • somatostatin transcription factor 1
  • insulin promoter factor 1, homeodomain transcription factor
  • Insulin promoter factor 1
  • Somatostatin-transactivating factor 1
  • Insulin upstream factor 1
  • Glucose-sensitive factor
  • Islet/duodenum homeobox-1
Background Information Transcription factor PDX1, also known as pancreatic and duodenal homeobox 1, activates expression of the insulin and somatostatin genes. This protein is a key regulator of islet peptide hormone expression and also plays an essential role in pancreatic development. It has been shown to interact with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). This protein also interacts with the methyltransferase SETD7. Mutations in this gene may be involved in several disorders of the pancreas or in diabetes mellitus.
References
Product Information
Format Serum
Control
  • Mouse pancreatic β T-cell lysate
Presentation Unpurified rabbit polyclonal without a preservative.
Applications
Application Anti-PDX1 (rabbit) Antibody is a Rabbit Polyclonal Antibody for detection of PDX1 also known as pancreatic & duodenal homeobox 1, somatostatin transcription factor 1, Insulin promoter factor 1 & has been validated in WB & IHC.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application Notes Immunohistochemistry Analysis: 1:500 dilution from a representative lot detected PDX1 in normal human pancreas tissue.
Biological Information
Immunogen GST-tagged recombinant protein corresponding to the N-terminus of mouse PDX1.
Epitope N-terminus
Host Rabbit
Specificity This antibody recognizes the N-terminus of PDX1.
Isotype IgG
Species Reactivity
  • Mouse
  • Human
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • GSF
  • IDX-1
  • STF-1
  • IUF1
  • PDX-1
  • MODY4
  • IPF1
  • IUF-1
  • IPF-1
Purification Method Unpurified
UniProt Number
UniProt Summary FUNCTION: Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'.

SUBUNIT STRUCTURE: Interacts with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with the methyltransferase SETD7 By similarity. Interacts with SPOP.

SUBCELLULAR LOCATION: Nucleus.

TISSUE SPECIFICITY: Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells).

DEVELOPMENTAL STAGE: At 8.5 dpc, detected in the gut epithelium from which the pancreatic buds are formed. Transient expression in pancreatic ducts, endocrine and acinar cells. Down-regulated around 10.5 dpc when expression becomes restricted to differentiated beta-cells.

DOMAIN: The Antp-type hexapeptide mediates heterodimerization with PBX on a regulatory element of the somatostatin promoter (By Similarity).

The homeodomain, which contains the nuclear localization signal, not only mediates DNA-binding, but also acts as a protein-protein interaction domain for TCF3(E47), NEUROD1 and HMG-I(Y) (By Similarity).

PTM: Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration.

SEQUENCE SIMILARITIES: Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily.

Contains 1 homeobox DNA-binding domain.
Molecular Weight ~ 39 kDa Observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in mouse pancreatic β T-cell lysate.

Western Blot Analysis: 1:1,000 dilution of this antibody detected PDX1 on 10 µg of mouse pancreatic β T-cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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