Anti-LMX-1 (rabbit polyclonal) - 炼石商城

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Anti-LMX-1 (rabbit polyclonal)

市场价：: 0.00

促销价：: ¥0.00

货号：AB10533

品牌：Millipore 密理博

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北京朝阳

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
M, R, Ht	WB	Rb	Serum	Polyclonal Antibody

Description
Catalogue Number	AB10533
Description	Anti-LMX-1 Antibody
Alternate Names	LIM homeobox transcription factor 1, alpha LIM/homeobox protein 1.1 LIM/homeobox protein LMX1A
Background Information	LMX-1 is a transcription factor that belongs to the LIM-homeodomain (LIM-HD) transcription factor family. It is induced within the ventral midbrain as a response to early signaling. LMX-1 is a necessary component for the development of the roof plate and for CNS dorsal cell date specification and the development of vertebrae. It is Expressed in roof plate, an organizational locus found in the dorsal CNS that functions to moderate the differentiation and specification of adjacent neurons through the secretion of signaling molecules such as WNT and BMP. Recent studies have indicated that LMX-1 has high potential for stimulating the production of mesencephalic dopamine neurons(mesDA) for the therapeutic treatment Parkinson disease, a condition characterized by dopaminergic neurotransmission decline resulting from the progression of mesDA neuronal degeneration within the substantia nigra pars compacta (SN).

References

Product Information
Format	Serum
Control	Mouse testis tissue lysate
Presentation	Unpurified rabbit polyclonal serum containing 0.05% sodium azide.

Applications
Application	Anti-LMX-1 Antibody is an antibody against LMX-1 for use in WB.
Key Applications	Western Blotting

Biological Information
Immunogen	GST-tagged recombinant protein corresponding to the C-terminus of hamster LMX-1.
Epitope	C-terminus
Host	Rabbit
Specificity	This antibody recognizes LMX-1.
Isotype	IgG
Species Reactivity	Mouse Rat Hamster
Species Reactivity Note	Demonstrated to react with mouse and rat. Predicted to react with hamster based on 100% sequence homology.
Antibody Type	Polyclonal Antibody
Entrez Gene Number	AAB62320
Gene Symbol	LMX-12 LMX1.1 LMX-1.1 LMX1
Purification Method	Unpurified
UniProt Number	Q04650
UniProt Summary	FUNCTION: Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity). SUBCELLULAR LOCATION: Nucleus. SEQUENCE SIMILARITIES: Contains 1 homeobox DNA-binding domain. Contains 2 LIM zinc-binding domains.
Molecular Weight	~50 kDa observed.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blot in mouse testis tissue lysate. Western Blot Analysis: 1:1,000 dilution of this antibody detected LMX-1 on 10 µg of mouse testis tissue lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Packaging Information
Material Size	100 µL

Transport Information

Supplemental Information

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