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Anti-phospho-LKB1 (Ser307) (rabbit polyclonal)

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货号：09-478

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R, B, Eq WB, DB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number 09-478
Description Anti-phospho-LKB1 (Ser307) Antibody
Alternate Names
  • Renal carcinoma antigen NY-REN-19
  • Serine/threonine-protein kinase LKB1
  • polarization-related protein LKB1
  • serine/threonine kinase 11
  • serine/threonine kinase 11 (Peutz-Jeghers syndrome)
  • serine/threonine protein kinase 11
Background Information LKB1 is a serine-threonine protein kinase and member of the calcium calmodulin family. LKB1 acts as a tumor suppressor and plays an important role in the regulation of many cellular processes. It is expressed in all tissues including pancreatic, liver, testicular, cardiac, and skeletal muscle tissue. Mutations in LKB1 result from unregulated cell growth and tumor formation that are associated with Peutz-Jehgers syndrome.
References
Product Information
Format Affinity Purified
Control
  • Modified and non-modified peptides of phosphorylated and non-phosphorlyated LKB1 protein
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Applications
Application Anti-phospho-LKB1 (Ser307) Antibody is an antibody against phospho-LKB1 (Ser307) for use in WB, DB.
Key Applications
  • Western Blotting
  • Dot Blot
Application Notes Western Blot Analysis: A previous lot was used by an independent laboratory in WB. (Xie, Z., et al. (2009). Molecular and Cellular Biology. 29(13):3582-3596.)
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to amino acids including and surrounding phosphorylated Ser307 of human LKB1.
Epitope Phosphorylated Ser307
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes LKB1 when phosphorylated at Ser307.
Species Reactivity
  • Human
  • Mouse
  • Rat
  • Bovine
  • Horse
Species Reactivity Note Demonstrated to react with human. Predicted to react with mouse, rat, bovine, and equine based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq].
Gene Symbol
  • STK11
  • LKB1
  • PJS
Modifications
  • Phosphorylation
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.

CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

COFACTOR: Magnesium or Manganese.

ENZYME REGULATION: Activated by binding of a complex consisting of CAB39 and STRAD or CAB39 and ALS2CR2.

SUBUNIT STRUCTURE: Found in a ternary complex composed of SMAD4, STK11 and STK11IP. Interacts with SMAD4 and STK11IP.

SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2.

TISSUE SPECIFICITY: Ubiquitously expressed. Strongest expression in testis and fetal liver.

PTM: Phosphorylated by a cAMP-dependent protein kinase By similarity.

INVOLVEMENT IN DISEASE: Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) [MIM:175200]. PJS is a rare hereditary disease in which there is predisposition to benign and malignant tumors of many organ systems. PJS is an autosomal dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer.

Defects in STK11 have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT).

SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.

Contains 1 protein kinase domain.
Molecular Weight ~ 49 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Dot Blot in modified and non-modified peptides of phosphorylated and non-phosphorlyated LKB1 protein.

Dot Blot Analysis: 1 µg/mL of this antibody detected LKB1 in modified and non-modified peptides of phosphorylated and non-phosphorlyated LKB1 protein.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 200 µL
Transport Information
Supplemental Information
Specifications

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