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Anti-Interleukin 18 (IL-18), clone CPTC-IL18-1 (mouse monoclonal)

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货号：04-1503

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M FC, WB, ICC, IHC R Purified Monoclonal Antibody
Description
Catalogue Number 04-150
Description Anti-AIRE Antibody, clone 5H12
Alternate Names
  • Autoimmune regulator
  • Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog
  • APECED protein homolog
  • AIRE
Background Information AIRE (Autoimmune Regulator) is a human gene that is expressed primarily in the thymus. It causes transcription of a wide selection of organ-specific genes, reducing the threat of autoimmunity occurring by allowing the elimination of autoreactive T cells via negative selection. Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendo-crinopathy-candidiasis-ectodermal dystrophy (APECED). Disruption of AIRE results in the development of a range of autoimmune diseases, the most common clinical conditions in the syndrome are hypoparathyroidism, primary adrenocortical failure and chronic mucocutaneous candidiasis. Aire functions through initiating the transcription of a diverse set of self-antigens, such as insulin, in the thymus. This expression then allows maturing thymocytes to become tolerant towards peripheral organs, thereby suppressing autoimmune disease. Aire is atranscriptional regulator protein that binds to DNA as dimer and tetramer, but not as a monomer. It forms nuclear bodies and interacts with the transcriptional coactivator CBP (CREBBP). At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD).
References
Product Information
Format Purified
Presentation Purified rat monoclonal IgG2cκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Detect AIRE using this rat monoclonal antibody, Anti-AIRE Antibody, clone 5H12 validated for use in Flow Cytometry, western blotting, ICC & IHC.
Key Applications
  • Flow Cytometry
  • Western Blotting
  • Immunocytochemistry
  • Immunohistochemistry
Application Notes Western Blotting Analysis: A representative lot from an independent laboratory detected AIRE in AIRE transfected COS cells (Hubert, F. X., et al. (2008). J Immunol. 180(6):3824-3832.).

Immunohistochemistry Analysis: A representative lot from an independent laboratory detected AIRE in mouse thymus sections (Hubert, F. X., et al. (2008). J Immunol. 180(6):3824-3832.).

Immunocytochemistry Analysis: A representative lot from an independent laboratory detected AIRE in mouse thymic epithelial cells (Guerau-de-Arellano, M., et al. (2009). J Exp Med. 206(6):1245-1252.).
Biological Information
Immunogen Linear peptide corresponding to the C-terminus of mouse AIRE.
Clone 5H12
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rat
Isotype IgG2cκ
Species Reactivity
  • Mouse
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • Aire
Purification Method Protein G Purified
UniProt Number
Molecular Weight 60 kDa calculated. Many isoforms are known to exist.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Flow Cytometry in mouse primary splenocytes.

Flow Cytometry Analysis: 4 µg of this antibody detected AIRE in 1X10E6 mouse primary splenocytes.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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