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Anti-Kallikrein-3 (KLK3) (C-term) (rabbit polyclonal)

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货号：AB10428

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB Rb Purified Polyclonal Antibody
Description
Catalogue Number AB10428
Description Anti-Kallikrein-3 (KLK3) (CT) Antibody
Alternate Names
  • P-30 antigen
  • Kallikrein-3
  • kallikrein-related peptidase 3
Background Information Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK3 is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein.
References
Product Information
Format Purified
Control
  • Western Blot : Mouse brain lysate.
Presentation Purified in PBS with 0.09% NaN3.
Applications
Application This Anti-Kallikrein-3 (KLK3) (C-term) Antibody is validated for use in WB for the detection of Kallikrein-3 (KLK3) (C-term).
Key Applications
  • Western Blotting
Biological Information
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human KLK3.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity The antibody reacts with the 29 kDa KLK3 antigen.
Species Reactivity
  • Human
  • Mouse
  • Rat
Species Reactivity Note Reacts with human, mouse and rat. Other species have not been tested.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. [provided by RefSeq]
Gene Symbol
  • APS
  • EC 3.4.21.77
  • Gamma-seminoprotein
  • KLK2A1
  • Kallikrein-3
  • PSA
  • Semenogelase
  • Seminin
  • hK3
Purification Method Saturated Ammonium Sulfate (SAS)
UniProt Number
UniProt Summary FUNCTION: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
CATALYTIC ACTIVITY: Preferential cleavage: -Tyr-|-Xaa-.
SUBCELLULAR LOCATION: Secreted.
SEQUENCE SIMILARITIES: Belongs to the peptidase S1 family. Kallikrein subfamily.
Contains 1 peptidase S1 domain.
Molecular Weight ~31 kDa observed.
Band may migrate from the calculated 29 kDa to ~31 kDa on western blot.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Western Blot Analysis: 1:250 dilution of this antibody detected KLK3 on mouse brain lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Store at 2-8°C for 6 months from date of receipt. For long term storage, store at -20°
Packaging Information
Material Size 400 µl
Transport Information
Supplemental Information
Specifications

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