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Anti-FOXP1 (rabbit polyclonal)

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货号：AB2277

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R, B, Rhesus Macaque WB, ICC, IHC Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB2277
Description Anti-FOXP1 Antibody
Alternate Names
  • fork head-related protein like B
  • forkhead box P1
  • glutamine-rich factor 1
Background Information Forkhead box protein 1 (FOXP1) is a member of the Forkhead family of transcription factors, which have been characterized as transcriptional repressors and activators, and as having a DNA-binding domain distinguished by its formation of a winged-helix motif. FOXP1 is known to be an important regulator of airway morphogenesis, lung epithelial development, and early cardiac development. It is also known to have an important role in conjunction with NFκβ in the development of B-cells and the differentiation of macrophages. Splice variants give rise to four isoforms of FOXP1. The protein is known to form homodimers and heterodimers with FOXP2 and FOXP4. Studies have indicated FOXP1 as a potential inducer of oncogenesis when over expressed. The depletion and mutation of FOXP1 expression may lead to defects in embryonic cardiac, lung and esophagus epithelial development.
References
Product Information
Format Affinity Purified
Control
  • Jurkat cell lysate
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Applications
Application Anti-FOXP1 Antibody detects level of FOXP1 & has been published & validated for use in WB, IC, IH.
Key Applications
  • Western Blotting
  • Immunocytochemistry
  • Immunohistochemistry
Application Notes Immunohistochemistry Analysis: A 1:300 dilution of AB2277 from a previous lot detected FOXP1 in inflammatory skin disorder and normal human kidney-glomerulus tissue.

Immunocytochemistry Analysis: A 1:500 dilution from a previous lot detected FOXP1 in NIH/3T3, RAW264.7, and HeLa cells.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to the C-terminus of human FOXP1.
Epitope C-terminus
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes the C-terminus of FOXP1.
Species Reactivity
  • Human
  • Mouse
  • Rat
  • Bovine
  • Rhesus Macaque
Species Reactivity Note Demonstrated to react with human, mouse, and rat. Predicted to react with bovine, and rhesus monkey based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].
Gene Symbol
  • FOXP1
  • QRF1
  • 12CC4
  • HSPC215
  • hFKH1B
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Transcriptional repressor that plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B cell development (By similarity).

SUBUNIT STRUCTURE: Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1 (By similarity).

SUBCELLULAR LOCATION: Nucleus Probable.

DOMAIN: The leucine-zipper is required for dimerization and transcriptional repression By similarity.

INVOLVEMENT IN DISEASE: A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. Translocation t(9;3)(p13;p14.1) with PAX5.

SEQUENCE SIMILARITIES: Contains 1 C2H2-type zinc finger.

Contains 1 fork-head DNA-binding domain.

SEQUENCE CAUTION: The sequence AAF36135.1 differs from that shown. Reason: Frameshift at positions 531 and 545.
Molecular Weight FOXP1 has 4 isoforms observed at 75/73, 64 and 54 kDa.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in Jurkat cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected multiple isoforms of FOXP1 in 10 µg of Jurkat cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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