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Anti-Fms/CSF-1 R extracellular domain

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货号：06-174

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M FC, ICC, IP, WB Rb Serum Polyclonal Antibody
Description
Catalogue Number 06-174
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-Fms/CSF-1 Receptor Antibody, extracellular domain
Alternate Names
  • CSF-1R
References
Product Information
Format Serum
Presentation whole rabbit antiserum
Applications
Application This Anti-Fms/CSF-1 Receptor Antibody, extracellular domain is validated for use in FC, IC, IP, WB for the detection of Fms/CSF-1 Receptor.
Key Applications
  • Flow Cytometry
  • Immunocytochemistry
  • Immunoprecipitation
  • Western Blotting
Biological Information
Immunogen Rab9 rabbit skin fibroblast cells transfected with a fully activated (transforming) murine Fms gene
Host Rabbit
Specificity extracellular domain of mouse Fms encoded protein
Isotype IgG
Species Reactivity
  • Mouse
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction.
Gene Symbol
  • CSF1R
  • C-FMS
  • FMS
  • FIM2
  • c-fms
  • CSF-1-R
  • CSFR
  • CD115
Purification Method Antiserum
UniProt Number
UniProt Summary FUNCTION: SwissProt: P07333 # This protein is the receptor for CSF-1, it is a protein tyrosine-kinase transmembrane receptor.
SIZE: 972 amino acids; 107984 Da
SUBUNIT: Interacts with INPPL1/SHIP2 and THOC5 (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Expressed in bone marrow and in differentiated blood mononuclear cells.
SIMILARITY: SwissProt: P07333 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
Molecular Weight Observed molecular weight at ~220 kDa, theoretical molecular weight at 150-165 kDa. Lower molecular weight degradation products may also be detected.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoblot on FDC-P1/MAC11 cell lysates
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 200 µL
Transport Information
Supplemental Information
Specifications

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