Anti-PP2A (Protein Phosphatase-2A) (rabbit polyclonal IgG) - 炼石商城

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Anti-PP2A (Protein Phosphatase-2A) (rabbit polyclonal IgG)

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货号：06-222

品牌：Millipore 密理博

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M, R, Rb	IP, WB	Rb	Serum	Polyclonal Antibody

Description
Catalogue Number	06-222
Brand Family	Upstate
Trade Name	Upstate
Description	Anti-PP2A Antibody, C subunit

References

Product Information
Format	Serum
Control	Positive Control Included: Non-Stim A431 Cell Lysate (12-301). Other controls: HeLa whole cel lysate, mouse NIH3T3 cells
Presentation	Immunoaffinity Purified immunoglobulin in 150mM Tris, pH 7.4, 0.02% sodium azide, 50% glycerol and 5mg/ml BSA

Applications
Application	Anti-PP2A Antibody, C subunit is an antibody against PP2A for use in IP & WB.
Key Applications	Immunoprecipitation Western Blotting

Biological Information
Immunogen	peptide corresponding to the C-terminal amino acid residues 296-309 of human protein phosphatase 2A
Host	Rabbit
Specificity	Recognizes PP2A-subunit alpha and PP2A-subunit beta; does not react with PP1 or other protein phosphatases.
Isotype	IgG
Species Reactivity	Human Mouse Rat Rabbit
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NM_002715.2 NP_002706
Entrez Gene Summary	The protein encoded by this gene is the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.
Gene Symbol	PPP2CA PP2CA PP2A-alpha RP-C PP2Ac
Purification Method	Unpurified
UniProt Number	P67775 P62714
UniProt Summary	FUNCTION: SwissProt: P67775 # PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Can dephosphorylate SV40 large T antigen and p53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen. COFACTOR: Binds 1 iron ion per subunit; Binds 1 manganese ion per subunit SIZE: 309 amino acids; 35594 Da SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with NXN; the interaction is direct. SUBCELLULAR LOCATION:Cytoplasm. SIMILARITY: SwissProt: P67775 ## Belongs to the PPP phosphatase family. PP-1 subfamily.
Molecular Weight	36 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	routinely evaluated by immunoblot on a rabbit brain cytosol or in a human A431 RIPA cell lysate
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Packaging Information
Material Size	200 µg

Transport Information

Supplemental Information

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