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Qiagen 凯杰 Biosharp Omega

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Anti-MGLL (rabbit polyclonal)

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货号：ABS684

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB, IHC Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number ABS68
Description Anti-Fer Antibody
Alternate Names
  • Tyrosine-protein kinase Fer
  • Proto-oncogene c-Fer
  • Tyrosine kinase 3
  • p94-Fer
Background Information FER tyrosine kinase is involved in cadherin, PECAM-1, and integrin mediated cytoskeletal connections. More recent research has also linked FER to decreasing the innate immune response. FER has also been implicated in the control of lipopolysaccharide induced epithelial dysfunction. FER has been shown to be essential in microtubule characteristics in the oocyte meiotic spindle and could also play a role in germinal vesicle breakdown.
References
Product Information
Format Affinity Purified
Control
  • HEK293 cell lysate
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Detect Fer using this Anti-Fer Antibody validated for use in WB, IH.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application Notes Immunohistochemistry Analysis: 1:500 dilution of a representative lot of this antibody detected Fer in lymphoid cells within the germinal centers and outside the mantle zone of normal human tonsil tissue.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to human Fer.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Summary: Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. [provided by RefSeq].
Gene Symbol
  • FER
  • TYK3
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Tyrosine kinase of the non-receptor type. Probably performs an important function, perhaps in regulatory processes such as cell cycle control.

CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note: Associated with the chromatin.

TISSUE SPECIFICITY: Expressed in a variety of lymphoid cell lines.

SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. Contains 1 FCH domain. Contains 1 protein kinase domain. Contains 1 SH2 domain.
Molecular Weight ~90 kDa observed. Uncharacterized bands may be visible at ~38 and ~58 kDa in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in HEK293 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Fer on 10 µg of HEK293 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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