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Anti-CD2AP (rabbit polyclonal)

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货号：ABT411

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB, ICC Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number ABD41
Description Anti-Lymphoid-specific helicase (HELLS) Antibody
Alternate Names
  • LSH
  • Lymphoid-specific helicase
  • Proliferation-associated SNF2-like protein
  • SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6
Background Information A member of the SNF2 family of chromatin remodeling proteins, Lymphoid-specific helicase (HELLS, also known as Lsh) assumes various roles in normal development, survival, de novo or maintenance DNA methylation, gene silencing, and heterochromatin formation and organization. It is shown to serve as cancer progression marker in conjunction with CEP55 and FOXM1 for the detection of head and neck squamous cell carcinoma (HNSCC). It is also reported that expression of Lsh is crucial for meiotic progression in mouse spermatocytes. Lsh is shown to directly associate with the 5' DMR of the Cdkn1c promoter, and thereby regulate its gene expression. Additionally, Lsh is reported as a regulator of repressive chromatin at retrotransposons, and is demonstrated to mediate the silencing of stem cell-specific genes such as Oct4.
References
Product Information
Format Affinity Purified
Control
  • HeLa nuclear extract
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-Lymphoid-specific helicase (HELLS) Antibody is an antibody against Lymphoid-specific helicase (HELLS) for use in WB & IC.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application Notes Western Blot Analysis: 0.1 µg/mL from a representative lot detected Lymphoid-specific helicase in NIH/3T3 and L6 cell lysates.

Immunocytochemistry Analysis: 2 µg/mL from a representative lot detected Lymphoid-specific helicase in NIH/3T3, A431, and HeLa cells.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to the coiled-coil region of human Lymphoid-specific helicase.
Epitope Coiled-coil region
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes the coiled-coil region of Lymphoid-specific helicase.
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Gene Symbol
  • HELLS
  • PASG
  • SMARCA6
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis.

SUBCELLULAR LOCATION: Nucleus. Note: Closely associated with pericentric heterochromatin.

TISSUE SPECIFICITY: Highly expressed in proliferative tissues such as adult thymus and testis, and expressed at lower levels in uterus, small intestine, colon, and peripheral blood mononuclear cells. Also expressed in neoplastic cell lines including those derived from myeloid and lymphoid leukemias.
Molecular Weight ~95 kDa observed.
Nine isoforms are produced by alternative splicing with molecular weights at ~97, 95, 93, 90, 85, 81, 39, 36 and 14 kDa. Uncharacterized bands may be observed at ~35 kDa and ~60 kDa in some cell lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in HeLa nuclear extract.

Western Blot Analysis: 0.1 µg/mL of this antibody detected Lymphoid-specific helicase in HeLa nuclear extract.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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