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Anti-TNNT2 (rabbit polyclonal)

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货号：ABT369

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R, H IH(P), WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number ABT39
Description Anti-MFAP-2 (MAGP) Antibody
Alternate Names
  • Microfibrillar-associated protein 2
  • Microfibril-associated glycoprotein 1
  • MAGP
  • MAGP-1
Background Information Along with elastin, elaunin, oxytalan, and elastin-associated proteins fibrillin-1, microfibrillar-associated glycoprotein-1 (MAGP or MFAP-2) can be found within the juxtacanalicular tissue of the inner and outer walls and within the collector channel walls of human eyes perfused at low and high pressure, among other certain human tissues. MAGP-1 (MFAP-2) is shown to play a significant role in the support and distensibility of the juxtacanalicular region of these collector channels. It is also reported to inhibit LTB-1 binding to fibrillin-1, stimulate the phosphorylation of Smad2, and thereby mediate the subsequent extracellular deposition of latent TGFbeta.
References
Product Information
Format Affinity Purified
Control
  • Human kidney tissue lysate.
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-MFAP-2 (MAGP) Antibody is an antibody against MFAP-2 (MAGP) for use in IH(P) & WB.
Key Applications
  • Immunohistochemistry (Paraffin)
  • Western Blotting
Application Notes Immunohistochemistry Analysis: A 1:500 dilution of a previous lot detected MFAP-2 in rat supportive connective tissue.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to human MFAP-2 (MAGP).
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Species Reactivity
  • Rat
  • Human
Species Reactivity Note Demonstrated to react with Rat and Human.
Other homologies: Mouse (82% sequence homology).
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for involvement in the etiology of inherited connective tissue diseases. Four transcript variants encoding two different isoforms have been found for this gene.
Gene Symbol
  • MFAP2
  • MAGP1
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Component of the elastin-associated microfibrils.

SUBUNIT STRUCTURE: Forms a ternary complex with BGN and ELN.

SUBCELLULAR LOCATION: Secreted > extracellular space > extracellular matrix.
Molecular Weight ~21 kDa observed.
Uncharacterized bands may be observed at a molecular weight of ~37 kDa and ~68 kDa in some cell lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in human kidney tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected MFAP-2 in human kidney tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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