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Anti-PHACTR1 (rabbit polyclonal)

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货号：ABT415

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R, Eq, Ox WB, IH(P) Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number ABT45
Description Anti-Claudin-5 Antibody
Alternate Names
  • Claudin-5
  • Transmembrane protein deleted in VCFS
  • TMDVCF
Background Information Claudin-5, a transmembrane protein deleted in velo-cardio-facial syndrome (TMVCF), seems to be involved in endothelial tight junctions. Claudin-5 has been exclusively found in the cell-cell borders of endothelial cells. Lower claudin-5 levels in sinusoidal endothelial cells could lead to their dysfunction during liver injuries. Levels of claudin-5 in tumor vessels could be a potential marker for hepatocellular carcinoma prognosis. The loss of claudin-5 function has been linked to carcinogenesis.
References
Product Information
Format Affinity Purified
Control
  • Human lung tissue lysate
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-Claudin-5 Antibody detects level of Claudin-5 & has been published & validated for use in WB, IH(P).
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application Notes Immunohistochemistry Analysis: A 1:800 dilution from a representative lot detected Clausin-5 in prostate tissue.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to human Claudin-5 at the cytoplasmic domain.
Epitope Cytoplasmic Domain
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes Claudin-5 at the cytoplasmic domain.
Species Reactivity
  • Human
  • Mouse
  • Rat
  • Horse
  • Ox
Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat.
Predicted to react with Equine and Ox based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].
Gene Symbol
  • CLDN5
  • AWAL
  • TMVCF
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity).

SUBUNIT STRUCTURE: Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ (By similarity).

SUBCELLULAR LOCATION: Cell junction › tight junction. Cell membrane; Multi-pass membrane protein.

SEQUENCE SIMILARITIES: Belongs to the claudin family.
Molecular Weight ~17 kDa observed.
Molecular weights at ~17 kDa and 62 kDa may be observed depending on phosphorylation and glycosylation effects (Ishizaki, T., et al. (2003). Experimental Cell Research. 290:275–288).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in human lung tissue lysate.

Western Blot Analysis: 0.1 µg/mL of this antibody detected Claudin-5 in 10 µg of human lung tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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