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Anti-Na+/K+ ATPase a-1 (rabbit polyclonal)

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货号：06-520

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
B, R, H ICC, IP, WB Rb Purified Polyclonal Antibody
Description
Catalogue Number 06-520
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-Na+/K+ ATPase α-1 Antibody
Background Information Na+/K+ ATPase α-1 is a human gene and functions to maintain Na+ and K+ across the cell membrane which is important for osmoregulation. It is a component of (Na+/K+) ATPase, a transporter that catalyzes the hydrolysis of ATP and transports sodium and potassium ions across the plasma membrane. It also partners with Src and other signaling proteins. Binding of ouabain and other cardiotonic steroids to the (Na+/K+) ATPase activates Src, resulting in the assembly and activation of multiple signaling cascades. Binding of ouabain also induces a positive inotropic effect. Diseases associated with ATPase are Thyrotoxic periodic paralysis and hyperthyroidism. (References: Wikipedia and http://www.bioportfolio.com/gene/476-ATP1A1.html)
References
Product Information
Format Purified
Control
  • Rat Brain Microsomal Prep. lysate.
Presentation Purified antibody in buffer containing 0.1M Tris-Glycine (pH7.4) 150mM NaCl and 0.05% NaN3.
Applications
Application This Anti-Na+/K+ ATPase α-1 Antibody is validated for use in IC, IP, WB for the detection of Na+/K+ ATPase α-1.
Key Applications
  • Immunocytochemistry
  • Immunoprecipitation
  • Western Blotting
Biological Information
Immunogen GST-tagged ATPase.
Epitope Cytoplasmic domain
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Recognizes the α-1 subunit isoform of Na+/K+ ATPase.
Isotype IgG
Species Reactivity
  • Bovine
  • Rat
  • Human
Species Reactivity Note Rat and Human. Expected to cross-react with Rat-100%, Mouse-99%; human, pig, rabbit, monkey-96%.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene Symbol
  • ATP1A1
  • G00-119-711
  • Na
  • +K
  • MGC3285
  • MGC51750
Purification Method Protein A Purfied
UniProt Number
UniProt Summary FUNCTION: SwissProt: P05023 # This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
SIZE: 1023 amino acids; 112896 Da
SUBUNIT: Composed of three subunits: alpha (catalytic), beta and gamma.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
PTM: Phosphorylation on Tyr-10 modulates pumping activity (By similarity).
SIMILARITY: SwissProt: P05023 ## Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily.
Molecular Weight 112 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by Immunoprecipitation on rat brain microsomal prep. lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8ºC from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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