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Anti-MX1 (rabbit polyclonal)

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货号：ABF270

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M WB, ICC M Purified Monoclonal Antibody
Description
Catalogue Number MABF270
Description Anti-STING Antibody, clone S17G2C4B7
Alternate Names
  • Stimulator of interferon genes protein
  • Endoplasmic reticulum interferon stimulator
  • ERIS
  • hMITA
  • hSTING
  • Mediator of IRF3 activation
  • Transmembrane protein 173
Background Information Stimulator of interferon genes protein (UniProt Q86WV6; also known as Endoplasmic reticulum interferon stimulator, ERIS, hMITA, hSTING, Mediator of IRF3 activation, Transmembrane protein 173) is encoded by the TMEM173 (also known as ERIS, MITA, MPYS, SAVI, STING) gene (Gene ID 340061) in human. STING is an adaptor protein activated by cytosolic dsDNA or cyclic dinucleotides and plays a critical role in initiating innate responses to infection by various pathogens, including Herpes simplex virus (HSV). Once activated, STING translocates to the endoplasmic reticulum and activates the TBK1/IRF3 pathway that in turn mediates the upregulation of interferon (IFN) β. In addition, the DNA sensor IFI16 is also known to function as a STING ligand and potentiates STING-dependent sensing of viral infection by presenting cellular viral DNA to STING. STING is a four transmembrane (a.a. 21-41, 47-67, 87-106, 116-136) protein with both its N- and C-terminal ends exposed intracellularly (a.a. 1-20 and 137-379).The C-terminal cytoplasmic tail contains the c-di-GMP-binding domain (CBD; a.a. 153-340) with two c-di-GMP-binding regions (a.a. 162-167 & 238-241).
References
Product Information
Format Purified
Presentation Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-STING Antibody, clone S17G2C4B7 is an antibody against STING for use in Western Blotting, Immunocytochemistry.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application Notes Western Blotting Analysis: A 1:200 dilution from a representative lot detected the expression of exogenously transfected human and murine STING in HEK293T cells, as well as the endogenous STING in telomerase-immortalized human foreskin fibroblasts hTERT-BJ1 (Courtesy of Dr. Glen N. Barber, University of Miami School of Medicine, FL, U.S.A.).
Immunocytochemistry Analysis: A 1:50 dilution from a representative lot detected the expression of exogenously transfected human and murine STING in HEK293T cells, as well as the endogenous STING in telomerase-immortalized human foreskin fibroblasts hTERT-BJ1 (Courtesy of Dr. Glen N. Barber, University of Miami School of Medicine, FL, U.S.A.).
Biological Information
Immunogen His-tagged recombinant human STING C-terminal cytoplasmic domain fragment.
Epitope Amino acids 301-315.
Clone S17G2C4B7
Concentration Please refer to lot specific datasheet.
Host Mouse
Specificity Clone S17G2C4B7 recognizes an epitope in the C-terminal cytoplasmic domain of human and murine STING.
Isotype IgG1κ
Species Reactivity
  • Human
  • Mouse
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • TMEM173
  • ERIS
  • MITA
  • MPYS
  • SAVI
  • STING
Purification Method Protein G Purified
UniProt Number
Molecular Weight ~38 kDa observed. 42.19 kDa calculated.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blotting in HEK293T cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected STING in 50 µg of HEK293T cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 μg
Transport Information
Supplemental Information
Specifications

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