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Anti-MBNL, clone 3A4

市场价：: 0.00

促销价：: ¥0.00

货号：04-048

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB	M	Ascites	Monoclonal Antibody

Description
Catalogue Number	04-048
Brand Family	Upstate
Trade Name	Upstate
Description	Anti-MBNL Antibody, clone 3A4
Alternate Names	Muscleblind-like protein 1 muscleblind-like (Drosophila) Triplet-expansion RNA-binding protein DKFZp686P06174 KIAA0428 EXP35 EXP42 EXP40
Background Information	Myotonic dystrophy (DM1) is a neuromuscular disorder associated with repeated CTG triplets in the 3'-untranslated region of the DMPK gene. It is hypothesized that the CUG repeats in the mRNA form hairpins that sequester nuclear factors required for proper muscle development and maintenance. MBNL (muscleblind-like protein 1) is an RNA splicing factor that binds to the CUG repeats and is enriched at these mutant RNA foci. MBNL-deficient mice are often used as a model for myotonic muscular dystrophy and siRNA downregulation of MBNL in normal myoblasts results in abnormal insulin receptor splicing.

References

Product Information
Format	Ascites
Control	Jurkat cell lysate
Presentation	Mouse ascites IgG1 in buffer containing 0.05% sodium azide.

Applications
Application	Anti-MBNL Antibody, clone 3A4 is a Mouse Monoclonal Antibody for detection of MBNL also known as Muscleblind-like protein 1, Triplet-expansion RNA-binding protein & has been validated in WB.
Key Applications	Western Blotting
Application Notes	Western Blot Analysis: A 1:1000 dilution of this lot detected MBNL-1 on Jurkat cell lysate. Optimal working dilutions must be determined by the end user.

Biological Information
Immunogen	Recombinant MBNL-1 41 kDa isoform amino acids 116-182
Epitope	a.a. 116-182
Clone	clone 3A4
Host	Mouse
Specificity	Antibody recognizes MBNL-1
Isotype	IgG1
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_778225
Gene Symbol	GC03P153468
Purification Method	Ascites
UniProt Number	Q9NR56
Molecular Weight	42 kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Routinely evaluated by western blot on Jurkat cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Packaging Information
Material Size	100 µL

Transport Information

Supplemental Information

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