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Anti-SLC13A2 (rabbit polyclonal)

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货号：ABN573

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, IH(P) Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number ABN73
Description Anti-Neutral amino acid transporter (ASCT2) Antibody
Alternate Names
  • Neutral amino acid transporter B(0)
  • Baboon M7 virus receptor
  • RD114/simian type D retrovirus receptor
  • Sodium-dependent neutral amino acid transporter type 2
  • Solute carrier family 1 member 5
Background Information Neutral amino acid transporter, also known as ASCT2, is an alternate of the ASC (alanine-, serine-, cysteine-) transport system and is highly expressed in rat astroglia-rich cultures while not highly expressed in rat neuron-rich cultures. ASCT2 is also thought to be important in the glutamine release from cells. ASCT2 has been implicated in the growth and survival of cancer cells, therefore making it a possible target for cancer therapy. ASCT2 is thought to be a crucial neuronal neutral amino acid transporter.
References
Product Information
Format Affinity Purified
Control
  • Human placenta tissue lysate
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-Neutral amino acid transporter (ASCT2) Antibody detects level of Neutral amino acid transporter (ASCT2) & has been published & validated for use in WB, IH(P).
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application Notes Immunohistochemistry Analysis: 1:1000 dilution from a previous lot detected Neutral amino acid transporter in human prostate tissue.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to the N-terminus of Neutral amino acid transporter.
Epitope N-terminus
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes Neutral amino acid transporter at the N-terminus.
Species Reactivity
  • Human
Species Reactivity Note Demonstrated to react with human. No homology found to mouse or rat.
Other homologies: rhesus monkey (93% sequence homology).
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]).[supplied by OMIM].
Gene Symbol
  • SLC1A5
  • M7V1
  • AAAT
  • R16
  • ATBO
  • M7VS1
  • RDR
  • ATB
  • ASCT2
  • RDRC
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Has a broad substrate specificity, a preference for zwitterionic amino acids, and a sodium-dependence. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated amino acids, anionic amino acids, and cationic amino acids. Act as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Probable). Melanosome. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

TISSUE SPECIFICITY: Placenta, lung, skeletal muscle, kidney, pancreas, and intestine.

SEQUENCE SIMILARITIES: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A5 subfamily.
Molecular Weight ~ 57 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in human placenta tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Neutral amino acid transporter on 10 µg of human placenta tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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