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Anti-ENTPD1 (rabbit polyclonal)

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货号：ABN571

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M, H, R WB, IH(P), ICC Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number ABN51
Description Anti-Fox-3 Antibody
Alternate Names
  • RNA binding protein fox-1 homolog 3
  • Fox-1 homolog C
  • Hexaribonucleotide-binding protein 3
  • Neuronal nuclei antigen
  • NeuN antigen
Background Information RNA binding protein fox-1 homolog 3 (UniProt: Q8BIF2; also known as Fox-1 homolog C, Hexaribonucleotide-binding protein 3, Fox-3, Neuronal nuclei antigen, NeuN antigen) is encoded by the Rbfox3 (also known as D11Bwg0517e, Hrnbp3) gene (Gene ID: 52897) in murine species. Fox-3 acts as a pre-mRNA alternative splicing regulator. It regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD). It is widely expressed in brain, including in cerebral cortex, hippocampus, thalamus, caudate/putamen, cerebellum, and in the spinal cord (at protein level). However, Purkinje cells lack Fox-3 expression. It is also found in the retina in the ganglion cells and some cells in the inner nuclear layer, but is absent from the photoreceptor cells and most cells in the inner nuclear layer. In developing mouse it is expressed in the neural tube as early as day E9.5. Fox-3 expression is shown to be up-regulated by retinoic acid in p19 cells during neural differentiation. Knockout mice display significantly reduced brain weight, impaired neurofilament expression and decreased white matter volume, but normal total body mass. Five isoforms of Fox-3 have been described that are generated by alternative splicing.
References
Product Information
Format Affinity Purified
Control
  • Mouse e16 brain tissue lysate
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-Fox-3, Cat. No. ABN51, is a highly specific rabbit polyclonal antibody that targets Fox 3/NeuN and has been tested in Immunocytochemistry, Immunohistochemistry (Paraffin), and Western Blotting.
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
  • Immunocytochemistry
Application Notes Western Blotting Analysis: 2 µg/mL from a representative lot detected Fox-3 in mouse brain nuclear extract.

Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Fox-3 in mouse cerebral cortex, mouse hippocampus, and human cerebellum tissues.

Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected Fox-3 in E18 rat cortex cells.
Biological Information
Immunogen GST-tagged recombinant protein corresponding to the N-terminus of mouse Fox-3.
Epitope N-terminus
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes Fox-3 at the N-terminus.
Species Reactivity
  • Mouse
  • Human
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • Rbfox3
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: RNA-binding protein that regulates alternative splicing events (By similarity).

SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity).

SEQUENCE SIMILARITIES: Contains 1 RRM (RNA recognition motif) domain.
Molecular Weight ~46 kDa observed. An uncharacterized band appears at ~68 kDa in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in mouse e16 brain tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Fox-3 on 10 µg of mouse e16 brain tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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