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VHR 10ug

市场价：: 0.00

促销价：: ¥0.00

货号：14-594

品牌：Millipore 密理博

配送至：

北京朝阳

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数量：

EA (预计3-5工作日到货)

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Replacement Information

Description
Catalogue Number	14-594
Brand Family	Upstate
Trade Name	Upstate
Description	VHR Protein, 10 µg
Overview	N-terminal GST-tagged, recombinant VHR expressed in E. coli

References

Product Information

Applications
Application	N-terminal GST-tagged, recombinant VHR expressed in E. coli, for use in Phosphatase Assays.
Key Applications	Phosphatase Assay

Biological Information
Source	recombinant human full-length VHR expressed in E. coli
Specific Activity	For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number	NM_004090.2
Entrez Gene Summary	The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.
Gene Symbol	DUSP3 VHR
Protein Target	VHR
Purification Method	Glutathione-agarose
Target Sub-Family	Ser/Thr/Tyr phosphatase
UniProt Number	P51452
UniProt Summary	FUNCTION: SwissProt: P51452 # This protein shows activity both toward tyrosine-protein phosphate as well as with serine-protein phosphate. SIZE: 185 amino acids; 20478 Da SIMILARITY: SwissProt: P51452 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. & Contains 1 tyrosine-protein phosphatase domain.
Molecular Weight	47.8kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	routinely evaluated by phosphorylation of DiFMUP
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	6 months at -70°C

Packaging Information
Material Size	10 µg
Material Package	Also available in 250 µg size --call for pricing and availability and reference catalog number 14-594M when ordering the 250 µg size.

Transport Information

Supplemental Information

Specifications

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