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Nucleostemin

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货号：MAB4311

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M ELISA, WB, ICC M Culture Supernatant Monoclonal Antibody
Description
Catalogue Number MAB4311
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Nucleostemin Antibody
Background Information Nucleostemin has been identified as a nucleolar protein that plays a role in the self-renewal mechanism of a variety of stem cells. Analysis of gene expression showed that both undifferentiated ES cells, Neural & Hematopoietic stem cells and a number of cancer cells express Nucleostemin. Expression was not detected following stem cell differentiation into mature cell types. The identification of factors that influence self renewal are important for the development of therapeutic applications of stem cells and also for the development of cancer treatments. Monoclonal antibodies to Human nucleostemin will facilitate the analysis of self-renewal in both stem cells and cancer cells.
References
Product Information
Format Culture Supernatant
Presentation Static cell culture supernatant fluid
Applications
Application Detect Nucleostemin using this Anti-Nucleostemin Antibody validated for use in ELISA, WB & IC.
Key Applications
  • ELISA
  • Western Blotting
  • Immunocytochemistry
Biological Information
Immunogen Recombinant GST-Human fusion protein
Clone 9D5.3
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Isotype IgG2bκ
Species Reactivity
  • Human
  • Mouse
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • GNL3
  • C77032
  • Nucleostemin
  • NS
  • MGC800
  • NNP47
  • E2IG3
  • nucleostemin
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q9BVP2 # May be required to maintain the proliferative capacity of stem cells.
SIZE: 549 amino acids; 61997 Da
SUBUNIT: May interact with p53/TP53 via its basic domain (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity). Nucleus, nucleolus (By similarity). Note=Shuttles between the nucleus and nucleolus (By similarity).
DOMAIN: SwissProt: Q9BVP2 The basic domain (B) allows nucleolar localization in the absence of GTP. The intermediate domain (I) inhibits nucleolar localization by the B domain and is required for exit from the nucleolus. Exit from the nucleolus to the nucleoplasm requires both the I and the acidic (A) domains, and may be triggered by GTP hydrolysis (By similarity).
SIMILARITY: Belongs to the MMR1/HSR1 GTP-binding protein family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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