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Anti-SUMO-1

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货号：04-453

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
A WB Rb Purified Polyclonal Antibody
Description
Catalogue Number 09-409
Replaces 04-453
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-SUMO-1 Antibody
Background Information The small ubiquitin-related modifier SUMO-1 belongs to the growing family of ubiquitin-related proteins involved in post translational protein modification1. It is present in all eukaryotic kingdoms and is highly conserved from yeast to humans. SUMO-1 does not appear to target proteins for degradation but seems to be involved in the modulation of protein-protein interactions. An increasing number of SUMO-1 substrates are being described but three major substrates for SUMO-1 modification are RanGAP1 and PML proteins.
References
Product Information
Format Purified
Presentation 100 µL of purified by salt precipitation in PBS containing 0.01% sodium azide. Dilute to working strength with 50mM Tris-HCl buffer (pH 7.6) containing 1.5% sodium chloride and 1% normal goat serum (if a goat anti-rabbit IgG linker antibody is to be used).
Applications
Application Anti-SUMO-1 Antibody detects level of SUMO-1 & has been published & validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen Synthetic peptide corresponding to amino acid residues 11-101 of human SUMO-1.
Host Rabbit
Specificity Recognizes SUMO-1. This antibody shows no cross-reactivity with ubiquitin, multi-ubiquitin chains, SUMO2/3, UCRP, Nedd8, and FAT10.
Isotype IgG
Species Reactivity
  • All
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized.
Gene Symbol
  • SUMO1
  • sentrin
  • Sentrin
  • SMT3H3
  • OFC10
  • UBL1
  • DAP-1
  • SENP2
  • SMT3
  • PIC1
  • GMP1
  • SUMO-1
  • SMT3C
Purification Method Salt precipitation
UniProt Number
UniProt Summary FUNCTION: SwissProt: P63165 # Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1- SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4.
SIZE: 101 amino acids; 11557 Da
SUBUNIT: Interacts with SAE2, UBE2I, RANBP2, PIAS1 and PIAS2. Interacts with PARK2. Covalently attached to a number of proteins such as PML, RANGAP1, HIPK2, SP100, p53, p73-alpha, MDM2, JUN, DNMT3B and TDG. Also interacts with HIF1A, HIPK2, HIPK3, CHD3, EXOSC9, RAD51 and RAD52.
SUBCELLULAR LOCATION: Nucleus membrane. Nucleus speckle. Cytoplasm.
PTM: Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
SIMILARITY: SwissProt: P63165 ## Belongs to the ubiquitin family. SUMO subfamily. & Contains 1 ubiquitin-like domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at -20°C from date of shipment for up to 12 months.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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