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Qiagen 凯杰 Biosharp Omega

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HA1077 (dihydrochloride salt)

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货号：19-164

品牌：Millipore 密理博

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Replacement Information

重要规格表

Uni Prot Number
O75116, Q16513, O75582, P51812, P17612, P23443, Q15746
Description
Catalogue Number 19-164
Brand Family Upstate
Trade Name
  • Upstate
Description HA1077
References
Product Information
Presentation C14H17N3O2S2HCl
Applications
Key Applications
  • Kinase Assay
Application Notes Inhibits ROKa/ROCK II, PRK2, MSK1, Rsk2, PKA, p70 S6 Kinase, CaM Kinase and MLCK.
Biological Information
Entrez Gene Number
Entrez Gene Summary This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.
Gene Symbol
  • ROCK2
  • KIAA0619
Protein Target Rho kinase 2
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q16513 # Exhibits a preference for highly basic protein substrates (By similarity).
SIZE: 984 amino acids; 112035 Da
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
DOMAIN:SwissProt: Q16513 The C1 domain does not bind the diacylglycerol (DAG).
PTM: Autophosphorylated. & Activated by limited proteolysis with trypsin (By similarity).
SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 1 protein kinase domain. & Contains 3 REM (Hr1) repeats.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 1 year at 4°C
Packaging Information
Material Size 5 mg
Transport Information
Supplemental Information
Specifications

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