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Anti-ICAT (rabbit polyclonal)

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货号：ABC939

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H ICC, IP, WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number ABC939
Description Anti-ICAT Antibody
Alternate Names
  • Beta-catenin-interacting protein 1
  • ICAT
  • Inhibitor of beta-catenin and Tcf-4
Background Information Beta-catenin-interacting protein 1 (UniProt Q9NSA3; also known as Beta-catenin-interacting protein ICAT, Inhibitor of beta-catenin and Tcf-4) is encoded by the CTNNBIP1 (also known as ICAT) gene (Gene ID 56998) in human. Inhibitor of beta-catenin and TCF (ICAT) negatively regulates T-cell factor/lymphoid enhancer factor (TCF/LEF)–beta-catenin transcriptional activity by competing against TCF/LEF for beta-catenin binding. ICAT gene knockout leads to premature death of newborn mice with gut, kidney, and craniofacial anomalies, implicating an important role of ICAT in epithelial establishment/maintenance and neural crest cell differentiation. The motility of melanoma cells through 3D matrices in vitro relies on two interconvertible modes of movements. ICAT is reported to suppress the expression of developmentally downregulated 9 (NEDD9) of Wnt/beta-catenin signaling pathway in human Lu1205 melanoma cells, resulting in a shift from the Rac-dependent mesenchymal movement to the Rho/ROCK-dependent amoeboid motility in vitro and enhanced colonization of transplanted Lu1205 in the lungs of nude mice in vivo.
References
Product Information
Format Affinity Purified
Presentation Purified rabbit polyclonal antibody in buffer containing PBS with 0.05% sodium azide.
Applications
Application Detect ICAT/CTNNBIP1 using this rabbit Polyclonal Anti-ICAT Antibody, Cat. No. ABC939, validated for use in Immunocytochemistry, Western Blotting and Immunoprecipitation.
Key Applications
  • Immunocytochemistry
  • Immunoprecipitation
  • Western Blotting
Application Notes Immunoprecipitation Analysis: A representative lot co-immunoprecitated beta-catenin with ICAT from lysates of five human melanoma cell lines (Lu1205, WM852, Dauv-1, Mel501, and Skmel3) (Domingues, M.J., et al. (2014). Cancer Res. 74(7):1983-1995).
Western Blotting Analysis: A representative lot detected ICAT in Lu1205, Mel501, human melanoma cells, and Skmel3 (Domingues, M.J., et al. (2014). Cancer Res. 74(7):1983-1995).
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to the C-terminus of human ICAT.
Epitope C-terminus
Concentration Please refer to lot specific datasheet.
Host Rabbit
Species Reactivity
  • Human
Species Reactivity Note Human. Predicted to react with Rat, Mouse, Bovine, Xenopus, Zebrafish, Chicken based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • CTNNBIP1
  • ICAT
Purification Method Protein G Purified
UniProt Number
Molecular Weight ~9 kDa calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Immunocytochemistry in A431, HeLa, HUVEC and cells.

Immunocytochemistry Analysis: 4 µg/mL of this antibody detected ICAT in A431, HeLa, HUVEC cells.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 μg
Transport Information
Supplemental Information
Specifications

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