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PP2A伪 (Active Enzyme)

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货号：14-111-D

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 14-111-D
Brand Family Upstate
Trade Name
  • Upstate
Description PP2Aα
Overview Recombinant human PP2Aα, full-length with an N-terminal GST-tag
References
Product Information
Presentation 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Applications
Application Recombinant human PP2Aα, full-length with an N-terminal GST-tag for use in enzyme kinetics, screening inhibitors, and selectivity profiling.
Key Applications
  • Phosphatase Assay
Biological Information
Concentration 0.05 mg/ml
Purity ≥70%
Source Sf9 Insect Cells
Specific Activity 220 nmol/min/mg
Entrez Gene Number
Entrez Gene Summary This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A.
Gene Symbol
  • PPP2R1A
  • PR65A
  • MGC786
Target Sub-Family Ser/Thr phosphatase
UniProt Number
UniProt Summary FUNCTION: SwissProt: P30153 # The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.
SIZE: 589 amino acids; 65309 Da
SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9.
DOMAIN: SwissProt: P30153 Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.
SIMILARITY: Belongs to the phosphatase 2A regulatory subunit A family. & Contains 15 HEAT repeats.
Molecular Weight 59 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Kinase assay: PP2Aα was diluted with phosphatase dilution buffer to various concentrations. 10 µl of PP2Aα was mixed with 5 µl of substrate assay solution and 10 µl phosphatase dilution buffer and incubated at 37°C for 15 min. Reaction was read by adding 100 µl of BIOMOL GREEN Reagent and incubating for 30 min. at room temp.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for > 6 month at –80°C from date of receipt.
Packaging Information
Material Size 10 μg
Transport Information
Supplemental Information
Specifications

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