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CKD9/Cyclin T1 (Active Enzyme)

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货号：14-685M-D

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 14-685M
Brand Family Upstate
Trade Name
  • Upstate
Description Cdk9/Cyclin T1 Protein, active, 250 µg
Overview C-terminal 6His-tagged, fulllength recombinant, human cdk9 co-expressed with untagged, full-length human cyclin T1
References
Product Information
Applications
Application Active, C-terminal 6His-tagged, full length recombinant, human Cdk9 co-expressed with untagged, full-length human Cyclin T1, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Source expressed by baculovirus in Sf21 insect cells
Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS.
Gene Symbol
  • CDK9
  • C-2k
  • PITALRE
  • TAK
  • CDC2L4
  • C-2K
Protein Target CDK9/cyclin T1
Purification Method Ni2+/NTA-agarose
Target Sub-Family CMGC
UniProt Number
UniProt Summary FUNCTION: SwissProt: P50750 # Member of the cyclin-dependent kinase pair (CDK9/cyclin- T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II), SUPT5H and RDBP. The CDK9/cyclin-K complex has also a kinase activity toward CTD of RNAP II and can substitute for P-TEFb in vitro.
SIZE: 372 amino acids; 42778 Da
SUBUNIT: Associates with CCNT1/cyclin-T1 to form P-TEFb. P-TEFb forms a complex with AFF4/AF5Q31. Also associates with CCNK/cyclin-K. Component of a complex which is at least composed of HTATSF1/Tat-SF1, P-TEFb complex, RNA pol II, SUPT5H, and NCL/nucleolin. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Ubiquitous.
SIMILARITY: SwissProt: P50750 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain.
Molecular Weight 44kDa (cdk9) and 80.79kDa (cyclinT1)
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by phosphorylation of PDKtide (Catalog# 12-401)
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions stable for 6 months at -70°C from date of shipment
Packaging Information
Material Size 250 µg
Material Package Also available in 10 μg size (cat#14-685) and in bulk (cat# 14-685-K).
Transport Information
Supplemental Information
Specifications

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