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PI3 kinase (p110未/p85伪) (Active Enzyme)

市场价：
23.00
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¥0.00

货号：14-604M-D

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 14-604M-D
Brand Family Upstate
Trade Name
  • Upstate
Description PI3 kinase (p110δ/p85α)
Overview Complex of N-terminal GST recombinant full-length human p110δ, and recombinant full length, human p85α, coexpressed in a Baculovirus infected Sf9 cell expression system
References
Product Information
Presentation 25 mM Tris, pH 8.0, 69 mM NaCl, 1.35 mM KCl, 0.03% Tween-20, 3 mM DTT, and 50% glycerol
Applications
Application Complex of N-terminal GST recombinant full-length human p110δ, and recombinant full length, human p85α, coexpressed in a Baculovirus infected Sf9 cell expression system, for use in enzyme kinetics, screening inhibitors, and selectivity profiling.
Key Applications
  • Kinase Assay
Biological Information
Purity ≥75%
Source Sf9 insect cells
Specific Activity 500 pmol/min/µg.
Entrez Gene Number
Entrez Gene Summary Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. See MIM 602838. The class I PI3Ks display a broad phosphoinositide lipid substrate specificity and include p110-alpha (MIM 171834), p110-beta (MIM 602925), and p110-gamma (MIM 601232). p110-alpha and p110-beta interact with SH2/SH3-domain-containing p85 adaptor proteins (see MIM 171833) and with GTP-bound Ras.[supplied by OMIM]
Gene Symbol
  • PIK3CD
  • p110d
  • PI3K
  • p110D
  • p110delta
Target Sub-Family PI3K/PI4K
UniProt Number
UniProt Summary SIZE: 1044 amino acids; 119479 Da
SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Interacts with ERAS (By similarity).
TISSUE SPECIFICITY: Expressed predominantly in leukocytes.
PTM: Autophosphorylation on Ser-1039 results in the almost complete inactivation of the lipid kinase activity.
SIMILARITY: SwissProt: O00329 ## Belongs to the PI3/PI4-kinase family. & Contains 1 PI3K/PI4K domain.
Molecular Weight 146 kDa (p110δ), 84 kDa (p85α)
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Kinase assay: A 25 μl kinase reaction is conducted in a buffer containing 40 mM Tris-HCl (pH 7.5), 20 mM MgCl2, 100 uM ATP, 200 μM PI:PS substrate and p110δ/p85α for 17 minutes at 30°C. ATP reduction is detected using ADP-Glo™ Kinase Assay Platform
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for > 6 month at –80°C from date of receipt.
Packaging Information
Material Size 250 μg
Transport Information
Supplemental Information
Specifications

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