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PI3 kinase (p110伪/p85伪) (Active Enzyme)

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货号：14-602-D

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 14-602
Brand Family Upstate
Trade Name
  • Upstate
Description PI3 Kinase (p110α/p85α) Protein, active, 20 µg
Overview Complex of N-terminal His6-tagged recombinant full-length human p110α and untagged, recombinant, full length, human p85α
References
Product Information
Applications
Application Active complex of N-terminal His6-tagged recombinant full-length human p110α & untagged, recombinant, full length, human p85α. For use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Source Coexpressed by baculovirus in Sf21 insect cells
Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene Summary Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.
Gene Symbol
  • PIK3CA
  • PI3K
  • MGC142161
  • p110-alpha
  • MGC142163
Protein Target PI3Kα/p85α
Purification Method Ni2+/NTA-agarose
Target Sub-Family PI3K/PI4K
UniProt Number
UniProt Summary FUNCTION: SwissProt: P42336 # Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.
SIZE: 1068 amino acids; 124284 Da
SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Binds to IRS1 in nuclear extracts. Interacts with RUFY3 (By similarity).
DISEASE: SwissProt: P42336 # Defects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500]. & Defects in PIK3CA are associated with breast cancer [MIM:114480]. & Defects in PIK3CA are associated with epithelial ovarian cancer (EOC) [MIM:604370].
SIMILARITY: SwissProt: P42336 ## Belongs to the PI3/PI4-kinase family. & Contains 1 C2 domain. & Contains 1 PI3K/PI4K domain.
Molecular Weight p110α (125.3kDa) & p85α (83.7kDa)
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by PIProfiler
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 6 months at -70°C
Packaging Information
Material Size 20 µg
Material Package Also available in 250μg size as catalog # 14-602M - Call for pricing and availability.
Transport Information
Supplemental Information
Specifications

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