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PI3 kinase (p120Æ”)(Active Enzyme)

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货号：14-558-D

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 14-558
Brand Family Upstate
Trade Name
  • Upstate
Description PI3 Kinase (p120γ), 20 µg
Overview N-terminal His6-tagged recombinant full-length human PI 3-kinase (p120γ).
References
Product Information
Applications
Application For use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Source Expressed by baculovirus in Sf21 insect cells
Specific Activity For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene Summary This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.
Gene Symbol
  • PIK3CG
  • p110-gamma
  • PI3-kinase
  • PIK3
  • PI3K
  • PI3Kgamma
  • PTDINS-3-kinase
  • PI3CG
  • p120-PI3K
Protein Target PI3Kγ
Purification Method Ni2+/NTA-agarose
Target Sub-Family PI3K/PI4K
UniProt Number
UniProt Summary FUNCTION: SwissProt: P48736 # 3-phosphorylates the cellular phosphoinositide PtdIns- 4,5-biphosphate (PtdIns(4,5)P2) to produce PtdIns-3, 4,5- triiphosphate (PtdIns(3,4,5)P3). Links G-protein coupled receptor activation to the secondary messenger PtdIns(3,4,5)P3 production.
SIZE: 1102 amino acids; 126454 Da
SUBUNIT: Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit.
TISSUE SPECIFICITY: Pancreas, skeletal muscle, liver and heart.
SIMILARITY: SwissProt: P48736 ## Belongs to the PI3/PI4-kinase family. & Contains 1 PI3K/PI4K domain.
Molecular Weight 130kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated in the PIProfiler.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 6 months at -70°C
Packaging Information
Material Size 20 µg
Material Package Also available in 250μg size as catalog # 14-558M - Call for pricing and availability.
Transport Information
Supplemental Information
Specifications

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