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Anti-trimethyl STAT3 (Lys180) (rabbit polyclonal)

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货号：ABE1397

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M WB, PIA, IP Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number ABE1397
Description Anti-trimethyl STAT3 (Lys180) Antibody
Alternate Names
  • Signal transducer and activator of transcription 3
  • Acute-phase response factor
  • trimethyl STAT3 (Lys180)
Background Information Signal transducer and activator of transcription 3 (UniProt P40763; also known as Acute-phase response factor, DNA-binding protein APRF) is encoded by the STAT3 (also known as ADMIO, APRF, HIES) gene (Gene ID 6774) in human. STAT proteins are latent cytoplasmic transcription factors that have the dual function of signal transduction and activation of transcription. STATs are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus. The N-terminal region is highly homologous among the STAT proteins and surrounds a completely conserved arginine residue. STATs are a part of the JAK-STAT signaling pathway – a major pathway of the immune system. All cytokines transduce critical signals through this pathway. STAT3 is known to be activated by IFN alpha but not IFN beta. The transcription factors associated with STAT3 are cJun and cyclic AMP responsive enhancer binding protein (CREB). STAT3 gene knockout in mice is lethal at the early embryonic stage.
References
Product Information
Format Affinity Purified
Presentation Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application This Anti-trimethyl STAT3 (Lys180) Antibody is validated for use in Western Blotting, Peptide Inhibition Assay, Immunoprecipitation for the detection of trimethyl STAT3 (Lys180).
Key Applications
  • Western Blotting
  • Peptide Inhibition Assay
  • Immunoprecipitation
Application Notes Immunoprecipitation Analysis: 5.0 µg from a representative lot immunoprecipitated STAT3 trimethylated on Lys180 in 0.5 mg of mouse embryonic stem cell lysate.
Peptide Inhibition Assay: Target specificity of a representative lot was confirmed by immunogen peptide blocking prior to Western blotting analysis (0.5 µg/mL) ) of mouse embryonic stem cell lysate (10 µg/lane) . Only the immunogen peptide, but not the corresponding peptide without the Lys180 trimethylation modification, blocked the detection of the target band.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to the STAT3 K180me3 of human trimethyl STAT3 (Lys180)
Epitope STAT3 K180me3
Concentration Please refer to lot specific datasheet.
Host Rabbit
Specificity Trimethylation site is present in all three human spliced isoforms. Reactivity toward Stat3 with mono- or dimethylated Lys180 has not been tested.
Species Reactivity
  • Mouse
Species Reactivity Note Mouse. Predicted to react with Human, Rat, Bovine, Chicken, Porcine, Orangatan based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • STAT3
  • APRF
Modifications
  • Methylation
Purification Method Affinity Purfied
UniProt Number
Molecular Weight ~88 kDa observed. Uncharacterized band(s) may appear in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blotting in mouse embryonic stem cell lysate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected STAT3 trimethylated on Lys180 in 10 µg of mouse embryonic stem cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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