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Anti-GABPB-1/NRF2b (rabbit polyclonal)

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货号：ABE1048

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, ChIP, EMSA Rb Serum Polyclonal Antibody
Description
Catalogue Number ABE1048
Description Anti-GABPB-1/NRF2b Antibody
Alternate Names
  • GA-binding protein subunit beta-1
  • GABP subunit beta-1
  • GABPB-1
  • GABP subunit beta-2
  • GABPB-2
  • Nuclear respiratory factor 2
  • Transcription factor E4TF1-47
  • Transcription factor E4TF1-53
  • GABPB-1/NRF2b
Background Information GA-binding protein subunit beta-1 (EC 3.2.1.3; UniProt Q06547; also known as GABP subunit beta-1, GABP subunit beta-2, GABPB-1, GABPB-2, Nuclear respiratory factor 2, Transcription factor E4TF1-47, Transcription factor E4TF1-53) is encoded by the GABPB1 (also known as E4TF1, E4TF1B, GABPB, GABPB2, NRF2B1, NRF2B2) gene (Gene ID 2553) in human. Initially identified through their interactions with cytochrome C and cytochrome oxidase promoters, GABP (NRF-2) and the related nuclear respiratory factor NRF-1 target many nuclear genes essential for mitochondrial respiratory function, including the mitochondrial transcription specificity factors TFB1M and TFB2M. GABP plays an anti-oxidant, pro-survival role in mitochondrial biogenesis process. GABP is a tetrameric complex composed of the NRF-2alpha (GABPA) and the NRF-2beta (GABPB) subunits. GABPA binds DNA via its ETS domain, and it recruits GABPB, which activates transcription through a glutamine-rich region in its carboxy terminus. GABPB and PRC, a member of PGC-1 family of regulated coactivators, can both interact with host cell factor 1 (HCF-1). PRC can therefore associate with GABP indirectly via HCF-1 and participate in GABP-dependent expression of the mitochondrial transcription factors TFB1M and TFB2M.
References
Product Information
Format Serum
Presentation Rabbit polyclonal serum with 0.05% sodium azide.
Applications
Application This Anti-GABPB-1/NRF2b Antibody is validated for use in Western Blotting, Chromatin Immunoprecipitation (ChIP), Electrophoretic Mobility Shift Assay for the detection of GABPB-1/NRF2b.
Key Applications
  • Western Blotting
  • Chromatin Immunoprecipitation (ChIP)
  • Electrophoretic Mobility Shift Assay
Application Notes Chromatin Immunoprecipitation (ChIP) Analysis: A representative lot detected GABPB (NRF-2beta) occupancy at the TFB1M and TFB2M promoters by ChIP using human embryonic kidney 293FT chromatin preparations (Vercauteren, K., et al. (2008). J Biol Chem. 283(18):12102-12111).
Electrophoretic Mobility Shift Assay (EMSA): A representative lot caused a supershift of GABP A2/B2 (NRF-2 α2/β2) heterotetramer-DNA complex in EMSA using in vitro translated GABP (NRF-2) subunits and radiolabeled cytochrome oxidase subunit IV promoter fragment containing tandem GABP (NRF-2) recognition sites (Vercauteren, K., et al. (2008). J Biol Chem. 283(18):12102-12111).
Immunoprecipitation Analysis: A representative lot immunoprecipitated GABPB (NRF-2beta)-PRC complex from human embryonic kidney 293FT cell lysate (Vercauteren, K., et al. (2008). J Biol Chem. 283(18):12102-12111).
Western Blotting Analysis: A representative lot detected GABPB (NRF-2beta) in U2OS cell lysates (Gleyzer, N., and Scarpulla, R.C. (2011). J. Biol. Chem. 286(46):39715-39725).
Biological Information
Immunogen Recombinant protein corresponding to human GABPB-1/NRF2b.
Concentration Please refer to lot specific datasheet.
Host Rabbit
Specificity Expected to react with all 4 spliced variants: isoform 1 (GABPB-1, Beta-1), isoform 2 (Beta-2), isoform 3 (GABPB-2, Gamma-1), isoform 4 (Gamma-2)
Species Reactivity
  • Human
Species Reactivity Note Human. Predicted to react with murine and equine species based on high sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • GABPB1
  • E4TF1B
  • GABPB
  • GABPB2
Purification Method Unpurified
UniProt Number
Molecular Weight ~48 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: A 1:10,000 dilution of this antibody detected GABPB-1/NRF2b in 10 µg of HeLa cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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