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Anti-Glucagon receptor (rabbit polyclonal)

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货号：ABS551

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, IH(P) Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number ABS551
Description Anti-Glucagon receptor Antibody
Alternate Names
  • GL-R
  • Glucagon receptor
Background Information Glucagon receptor or GL-R (UniProt P47871) is encoded by the GCGR (also known as GGR) gene (Gene ID 2642) in human. Glucagon is a 29-amino acid peptide that stimulates glycogenolysis and gluconeogenesis in the liver to increase blood glucose. The receptor for glucagon is a class 2 (or class B) G protein-coupled receptor (GPCR) that signals through Gs to stimulate cAMP production. Mice lacking the glucagon receptor have mild hypoglycemia after fasting and exhibit hyperplasia of pancreatic alpha-cells. Because of its role in promoting hyperglycemia, the glucagon receptor presents a potential target for treatment of diabetes.
References
Product Information
Format Affinity Purified
Presentation Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application This Anti-Glucagon receptor Antibody is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of Glucagon receptor.
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application Notes Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Glucagon receptor in human pancreas.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human Glucagon receptor.
Epitope Fourth cytoplasmic domain
Concentration Please refer to lot specific datasheet.
Host Rabbit
Species Reactivity
  • Human
Species Reactivity Note Human. Predicted to react with Primate based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • GCGR
Purification Method Affinity Purfied
UniProt Number
Molecular Weight ~59 kDa observed. Target band appears larger than the calculated molecular weight of 54.0 kDa (Preform) and 51.3 kDa (mature) due to glycosylation. Lower molecular weight degradation band(s) can also be seen (Iwanij, V., et al. (1990). J. Biol Chem. 265(34):21302-21308).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blotting in human liver tissue lysate.

Western Blotting Analysis: 0.2 µg/mL of this antibody detected Glucagon receptor in 10 µg of human liver tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 μg
Transport Information
Supplemental Information
Specifications

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