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Rb X Neuronal Pentraxin 2

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货号：AB15520

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M ELISA, WB Rb Purified Polyclonal Antibody
Description
Catalogue Number AB15520
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Neuronal pentraxin 2 Antibody
Alternate Names
  • NPX2
Background Information Neuronal Pentraxins: A new family of putative integral membrane pentraxins or Neuronal pentraxins identified through interaction with a presynaptic snake venom toxin taipoxin. NPX1, NPX2 and NPXR (Neuronal Pentraxin Receptor), the three neuronal pentraxins represent a novel neuronal uptake pathway that may function during synapse formation and remodeling. The N-terminal half of neuronal pentraxins are 20-30% identical to previously identified pentraxins (CRP and SAP), the three neuronal pentraxins are 50% identical to each other and are significantly larger than the classical pentraxins (>50 versus 30kDa), suggesting that they may have additional novel functions. NPX2 (Neuronal Pentraxin 2), 429aa in mouse, 432 in rat and 431 in human (chr 7q21), mainly expressed in brain, pancrease, liver and testis. It is likely to play role in the modification of cellular properties that underlie long-term plasticity. NPX1, NPX2 has potential N-linked glycosylation sites.
References
Product Information
Format Purified
Presentation Liquid in 100 mM Tris, pH 7.5 and 0.1% BSA.
Applications
Application Detect Neuronal pentraxin 2 using this Anti-Neuronal pentraxin 2 Antibody validated for use in ELISA & WB.
Key Applications
  • ELISA
  • Western Blotting
Application Notes Western blot: 1-10 µg/mL using ECL.
Immunohistochemistry: Not tested. It is recommended that the antibody be tried at 2-20 µg/mL
ELISA: 1:10,000-1:100,000 using 50-100 ng of control peptide/well.
Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Synthetic peptide near the N-terminus of mouse NPX2
Host Rabbit
Species Reactivity
  • Mouse
Species Reactivity Note Other species have not yet been tested. The immunogen sequence is 100% conserved in rat, and 94% in human NPX2 and 82% in guinea pig apexin precursor P50.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • NPTX2
  • NP-II
  • NP2
  • NARP
Purification Method ImmunoAffinity Purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: P47972 # Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity).
COFACTOR: Binds 2 calcium ions per subunit (By similarity).
SIZE: 431 amino acids; 47042 Da
SUBCELLULAR LOCATION: Secreted (By similarity).
TISSUE SPECIFICITY: Brain, pancreas, liver, heart and skeletal muscle. Highest levels are seen in the testis.
SIMILARITY: SwissProt: P47972 ## Contains 1 pentaxin domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 50 µg
Transport Information
Supplemental Information
Specifications

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