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Anti-SNF2b/BRG1

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货号：07-478

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R IP, WB Rb Serum Polyclonal Antibody
Description
Catalogue Number 07-478
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-SNF2β/BRG1 Antibody
Overview The SNF2 family of proteins are ATP dependant chromatin remodeling enzymes. The gene encoding this protein is also refered to as SMARCA4.
Alternate Names
  • Probable global transcription activator SNF2L4
  • ATP-dependent helicase SMARCA4
  • SNF2-beta
  • BRG-1
  • Mitotic growth and transcription activator
  • Brahma protein homolog 1
  • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
Background Information The SWI-SNF complex is involved in the activation of transcription via the remodeling of nucleosome structure in an ATP-dependent manner. Brm (also designated SNF2α) and Brg-1 (also designated SNF2β) are the ATPase subunits of the mammalian SWI-SNF complex. Brm, Brg-1, Ini1 (integrase interactor 1, also designated SNF5), BAF155 (also designated SRG3) and BAF170 are thought to comprise the functional core of the SWI-SNF complex. Addition of Ini1, BAF155 and BAF170 to Brg-1 appears to increase remodeling activity. Other complex subunits are thought to play regulatory roles. hSNF2L and hSNF2H both appear to be homologs of Drosophila ISWI, a Brm related ATPase that is present in chromatin remodeling complexes other than SWI/SNF, including the NURF (nucleosome remodeling factor).
References
Product Information
Format Serum
Control
  • HeLa Nuclear Extract.
Presentation Rabbit polyclonal in buffer containing with 0.05% sodium azide with 30% glycerol.
Applications
Application Use Anti-SNF2β/BRG1 Antibody (rabbit polyclonal antibody) validated in IP, WB to detect SNF2β/BRG1 also known as Probable global transcription activator SNF2L4, ATP-dependent helicase SMARCA4, SNF2-beta, BRG-1.
Key Applications
  • Immunoprecipitation
  • Western Blotting
Application Notes Immunocytochemistry Analysis: A 1:250 dilution from a representative lot detected BRG1 in HeLa cells.
Biological Information
Immunogen GST-tagged recombinant protein corresponding to the Near N-Terminus of human SNF2β.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes the Near N-Terminus of SNF2B
Isotype IgG
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Alternatively spliced transcripts have been found for this gene, but their full-length natures have not been determined.
Gene Symbol
  • SMARCA4
  • BRG1
  • SNF2B
  • SNF2L4
Purification Method Unpurified
UniProt Number
UniProt Summary FUNCTION: SwissProt: P51532 # Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation.
SIZE: 1647 amino acids; 184646 Da
SUBUNIT: Interacts with NR3C1, PGR, SMARD1, TOPBP1 and ZMIM2/ZIMP7. Component of the BAF53 complex, at least composed of BAF53A, RUVBL1, SMARCA4/BRG1, and TRRAP, which preferentially acetylates histone H4 (and H2A) within nucleosomes.
SUBCELLULAR LOCATION: Nucleus.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: SwissProt: P51532 ## Belongs to the SNF2/RAD54 helicase family. & Contains 1 bromo domain. & Contains 1 helicase ATP-binding domain. & Contains 1 helicase C-terminal domain. & Contains 1 HSA domain.
Molecular Weight 200 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blotting in HELA NE cell lysate.
Western Blotting Analysis: A 1:4,000 dilution of this antibody detected SNF2B/BRG1 in 10 µg of HELA NE cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Packaging Information
Material Size 200 µL
Transport Information
Supplemental Information
Specifications

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