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Anti-HDAC8 (rabbit antiserum)

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货号：07-505

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M IP, WB Rb Serum Polyclonal Antibody
Description
Catalogue Number 07-505
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-HDAC8 Antibody
References
Product Information
Format Serum
Presentation 30% glycerol
Applications
Application Anti-HDAC8 Antibody is a Rabbit Polyclonal Antibody for detection of HDAC8 also known as histone deacetylase 8 & has been tested in IP & WB.
Key Applications
  • Immunoprecipitation
  • Western Blotting
Biological Information
Immunogen GST fusion protein corresponding to amino acids 305-377 of human HDAC8
Host Rabbit
Specificity HDAC8
Isotype IgG
Species Reactivity
  • Human
  • Mouse
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter.
Gene Symbol
  • HDAC8
  • HD8
  • RPD3
  • HDACL1
Purification Method Antiserum
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q9BY41 # Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
SIZE: 377 amino acids; 41758 Da
SUBUNIT: Interacts with PEPB2-MYH11, a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11 produced by the inversion Inv(16)(p13q22), a translocation associated with acute myeloid leukemia of M4EO subtype. The PEPB2-MYH1 fusion protein also interacts with RUNX1, a well known transcriptional regulator, suggesting that the interaction with HDAC8 may participate in the conversion of RUNX1 into a constitutive transcriptional repressor. Interacts with CBFA2T3.
SUBCELLULAR LOCATION: Nucleus. Note=Excluded from the nucleoli.TISSUE SPECIFICITY: Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas.
SIMILARITY: SwissProt: Q9BY41 ## Belongs to the histone deacetylase family. Type 1 subfamily.
MISCELLANEOUS: Its activity is inhibited by trichostatin A (TSA) and butyrate, two well known histone deacetylase inhibitors.
Molecular Weight 48 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoblot in in a nuclear extract of mouse liver
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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