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Anti-Poly(rC)-binding protein 2, clone 6A3.2 (mouse monoclonal)

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货号：MAB11056

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB, ICC M Purified Monoclonal Antibody
Description
Catalogue Number MAB11056
Description Anti-Poly(rC)-binding protein 2 Antibody, clone 6A3.2
Alternate Names
  • poly(rC) binding protein 2
  • heterogenous nuclear ribonucleoprotein E2
  • poly(rC)-binding protein 2
  • Alpha-CP2
Background Information Poly(rC)-binding protein 2 (also known as αCP2 and hnRNP E2) is a part of a highly conserved, widely expressed family of RNA-binding proteins. Every isoform belonging to the Poly(rC)-binding protein family is comprised of a characteristic repeat of three KH domains, a 70 amino acid hnRNP commonly found in a large variety of RNA binding proteins. The KH domain is necessary to the binding of RNA. Poly(rC)-binding protein 2 functions to bind mRNA through its KH domain in a manner that provides a high level of stability to the mRNA. Recent studies have identified 160 mRNAs that are consistently and specifically associated with Poly(rC)-binding protein 2 (Waggoner,2003). Expression of Poly(rC)-binding protein 2 has been observed in all tissues tested.
References
Product Information
Format Purified
Control
  • Hek293 cell lysate
Presentation Purified mouse monoclonal IgG3κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-Poly(rC)-binding protein 2 Antibody, clone 6A3.2 is an antibody against Poly(rC)-binding protein 2 for use in WB & IC.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application Notes Immunocytochemistry Analysis: 1:500 dilution of this antibody has been shown to detect Poly(rC)-binding protein 2 in A431 cells.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to human Poly(rC)-binding protein 2.
Epitope aa 204-217
Clone 6A3.2
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity This antibody recognizes Poly(rC)-binding protein 2.
Isotype IgG3κ
Species Reactivity
  • Human
  • Mouse
  • Rat
Species Reactivity Note Demonstrated to react with human. Predicted to react with mouse and rat based on 100% sequence homology.
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Gene Symbol
  • hnRNP-E2
  • HNRPE2
  • alpha-CP2
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: Major cellular poly(rC)-binding protein. Binds also poly(rU).

SUBUNIT STRUCTURE: Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1.

SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.

TISSUE SPECIFICITY: Detected in all tissues examined.

PTM: Phosphorylated. The non-phosphorylated form(s) exhibited the strongest poly(rC)-binding activity.

SS=EQUENCE SIMLARITIES: Contains 3 KH domains.
Molecular Weight ~39 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in Hek293 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Poly(rC)-binding protein 2 on 10 µg of Hek293 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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