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Anti-ADAM 9, disintegrin domain (rabbit polyclonal)

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货号：AB2959

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, Pm, Chp WB Rb Purified Polyclonal Antibody
Description
Catalogue Number AB2959
Replaces AB19025
Description Anti-ADAM 9 Antibody, disintegrin domain
Alternate Names
  • ADAM metallopeptidase domain 9 (meltrin gamma)
  • a disintegrin and metalloproteinase domain 9 (meltrin gamma)
  • Cellular disintegrin-related protein
  • Myeloma cell metalloproteinase
  • Metalloprotease/disintegrin/cysteine-rich protein 9
Background Information A disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) belongs to a family of transmembrane, membrane-anchored, disintegrin-containing proteins that are involved in several biological functions such as protein ectodomain shedding, cell fusion, and cell adhesion. ADAMs contain several characteristic domains, two of which, the protease and disintegrin domains, are noted for their homology to snake venom metalloprotease. The exact function of ADAM 9 is yet unknown, however it is widely distributed, is found within keratinocytes, and is ideally placed on the cell membrane, which some studies have suggested supports a role in cell migration and motility. Alternative splicing results in two isoforms; isoform 1 is found within the cell membrane and is considered a single-pass type 1 membrane protein, while isoform 2 is secreted. Mutations in ADAM 9 expression are causal to cone-rod dystrophy type 9 or CORD9 which is characterized by visible retinal pigment deposits and loss of cone photoreceptors leading and rod degeneration, ultimately resulting in severe loss of vision.
References
Product Information
Format Purified
Control
  • Human chondrocyte cell lysate
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, with 0.05% sodium azide.
Applications
Application Detect ADAM 9 using this Anti-ADAM 9 Antibody, disintegrin domain validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to the disintegrin domain of human ADAM 9.
Epitope disintegrin domain
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Species Reactivity
  • Human
  • Primate
  • Chimpanzee
Species Reactivity Note Demonstrated to react with human. Predicted to react with primate and chimpanzee based on 100% sequence homology.
Mouse and rat (90% sequence homology).
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Two alternative splice variants have been identified, encoding distinct isoforms. [provided by RefSeq].
Gene Symbol
  • ADAM9
  • Mltng
  • MDC9
  • ADAM12
  • MCMP
  • MCMP-PEN
  • MLTNG
  • Meltrin-gamma
Purification Method Protein A Purfied
UniProt Number
UniProt Summary FUNCTION: Probable zinc protease. May mediate cell-cell or cell-matrix interactions. Isoform 2 displays alpha-secretase activity for APP.

COFACTOR: Binds 1 zinc ion per subunit (Probable).

SIZE: 819 amino acids; 90556 Da

SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.

TISSUE SPECIFICITY: Widely expressed. Expressed in chondrocytes. Highest expression of isoform 2 found in liver and heart.

SIMILARITY: Contains 1 disintegrin domain. & Contains 1 EGF-like domain. & Contains 1 peptidase M12B domain.
Molecular Weight ~ 90 kDa observed. 2 isoforms are produced by alternative splicing: Isoform 1 at 91 kDa and Isoform 2 at 72 kDa.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in human chondrocyte cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected ADAM 9 in 10 µg of human chondrocyte cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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