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Rb X GABARAP

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货号：AB15415

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, R ICC, IHC, WB Rb Serum Polyclonal Antibody
Description
Catalogue Number AB15415
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-GABARAP Antibody
Alternate Names
  • Gamma-aminobutyric acid receptor-associated protein
  • GABA(A) receptor-associated protein
Background Information Autophagy is the process by which cells recycle cytoplasm and dispose of excess or defective organelles. This process is suggested to be involved development, differentiation, growth regulation and tissue remodeling in multicellular organisms. An important inhibitory neurotransmitter, GABA, acts on GABA receptors that are ubiquitously expressed in the CNS. GABARAP has been shown to play a important role in modulating the activities of GABA (A) receptors.
References
Product Information
Format Serum
Presentation Lyophilized. Reconstitute with 50 uL of sterile distilled water. Centrifuge to remove any insoluble material. Contains no preservative.
Applications
Application Anti-GABARAP Antibody detects level of GABARAP & has been published & validated for use in IC, IH & WB.
Key Applications
  • Immunocytochemistry
  • Immunohistochemistry
  • Western Blotting
Application Notes Western blot: 1:100-1:1,000
Immunocytochemistry: 1:100-1:1,000
Immunohistochemistry: 1:100-1:1,000
Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Synthetic peptide corresponding to a region within the N-terminus of human GABARAP protein.
Host Rabbit
Specificity GABARAP [Gamma-aminobutyric acid receptor-associated protein, GABA(A) receptor-associated protein].
Species Reactivity
  • Human
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton.
Gene Symbol
  • GABARAP
  • GABA
  • MM46
  • MGC120155
  • MGC120154
  • FLJ25768
Purification Method Serum
UniProt Number
UniProt Summary FUNCTION: SwissProt: O95166 # May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton (By similarity).
SIZE: 117 amino acids; 13918 Da
SUBUNIT: Interacts with GPHN and NSF (By similarity). Interacts with GABRG2, beta-tubulin and ULK1.
SUBCELLULAR LOCATION: Intracytoplasmic membrane (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Largely associated with intracellular membrane structures including the Golgi apparatus and post-synaptic cisternae. Colocalizes with microtubules (By similarity).
TISSUE SPECIFICITY: Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.
SIMILARITY: SwissProt: O95166 ## Belongs to the MAP1 LC3 family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain lyophilized material frozen at -20°C to -70°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1, ACS or better grade) can be added for additional stability.
Packaging Information
Material Size 50 µL
Transport Information
Supplemental Information
Specifications

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