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Anti-PLCb-1 (mixed ms monoclonal IgG)

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货号：05-164

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
B, H, M, R IP M Purified Monoclonal Antibody
Description
Catalogue Number 05-164
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-PLCβ-1 Antibody
References
Product Information
Format Purified
Presentation 100mM Tris-glycine, pH 7.4, 0.15M NaCl with 0.05% sodium azide
Applications
Application Detect PLCβ-1 using this Anti-PLCβ-1 Antibody validated for use in IP.
Key Applications
  • Immunoprecipitation
Biological Information
Immunogen Mixed monoclonal antibodies raised against purified bovine PLCβ-1
Host Mouse
Specificity PLCβ-1, also recognize the 100kDa and 41kDa fragments of PLCβ-1.1
Isotype mixed IgGs
Species Reactivity
  • Bovine
  • Human
  • Mouse
  • Rat
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene.
Gene Symbol
  • PLCB1
  • PLC-beta-1
  • PLC-154
  • PLC-I
  • KIAA0581
  • FLJ45792
  • 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate
  • PI-PLC
  • inositoltrisphosphohydrolase
Purification Method Protein G Chromatography
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q9NQ66 # The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
COFACTOR: Calcium.
SIZE: 1216 amino acids; 138567 Da
SIMILARITY: SwissProt: Q9NQ66 ## Contains 1 C2 domain. & Contains 1 PI-PLC X-box domain. & Contains 1 PI-PLC Y-box domain.
MISCELLANEOUS: The receptor-mediated activation of PLC-beta-1 is mediated by two G-protein alpha subunits, alpha-Q and alpha-11.
Molecular Weight 150 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoprecipition of PLCβ-1 from a bovine brain membrane preparation, subsequent immunoblotting performed by the antibody
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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