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Anti-Insulin-like Growth Factor II (IGF-II) (mouse monoclonal IgG1)

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货号：05-166

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, R ELISA, IP, ICC, NEUT, WB M Purified Monoclonal Antibody
Description
Catalogue Number 05-166
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-IGF-II Antibody, clone S1F2
Background Information Human Insulin-like Growth Factor II (IGFII) contains 67 amino acids and shares similar structural features with IGFI, including a 62% sequence homology. In human plasma, IGFI and IGFII are associated with IGF-binding proteins that transport the polypeptides and partially regulate their actions in vivo. In addition to the insulin receptor, IGFII binds to two forms of IGF receptors, both of which are widely distributed in different tissues and cultured cells. IGFII is mitogenic for a variety of cultured cells, including mouse 3T3 cells,12 normal rat kidney cells, human or chicken fibroblasts and MCF-7 human breast carcinoma cells.
References
Product Information
Format Purified
Control
  • Human head and neck tumours, angioma tissues
Presentation Purified mouse monoclonal IgG1 in buffer containing PBS, pH 7.4., purified by ammonium sulfate precipitation and DEAE-cellulose chromatography. Frozen solution.
Applications
Application Detect IGF-II using this Anti-IGF-II Antibody, clone S1F2 validated for use in ELISA, IP, IC, NEUT & WB.
Key Applications
  • ELISA
  • Immunoprecipitation
  • Immunocytochemistry
  • Neutralizing
  • Western Blotting
Application Notes Neutralization: 10 μg/mL of a previous lot inhibited the stimulatory effects of IGF-II (10 ng/mL) on DNA synthesis in chicken embryo fibroblasts. Cell viability was assessed using an ATP endpoint assay (ATPLiteÔ-M, Packard Instruments). Previous lots of antibody were tested to inhibit IGF-II-dependent incorporation of [3H]-thymidine
Biological Information
Immunogen Partially purified rat IGF-II. Clone S1F2
Clone S1F2
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity This antibody detects IGF-II.
Isotype IgG1
Species Reactivity
  • Human
  • Rat
Species Reactivity Note Recognizes rat and human IGF-II. Less than 10% cross-reactivity to human IGF-I (Tanaka, H, 1989; Suzuki, T, 1989).
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the insulin family of polypeptide growth factors that is involved in development and growth. It is an imprinted gene and is expressed only from the paternally inherited allele. It is a candidate gene for eating disorders. There is a read-through, INS-IGF2, which aligns to this gene at the 3' region and to the upstream INS gene at the 5' region. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
Gene Symbol
  • IGF2
  • FLJ22066
  • FLJ44734
  • pp9974
  • IGF-II
  • INSIGF
  • C11orf43
Purification Method Ammonium sulfate precipitation and DEAE-cellulose chromatography
UniProt Number
UniProt Summary FUNCTION: SwissProt: P01344 # The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.
SIZE: 180 amino acids; 20140 Da
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: SwissProt: P01344 ## Belongs to the insulin family.
Molecular Weight ~7 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blotting on HeLa acid extracted nuclear preps (positive) and recombinant Histone H3 (negative).

Western Blotting Analysis:
1:5,000 – 1:10,000 dilution of this antibody was used to detect trimethylated-Histone H3 (Lys4) in HeLa nuclear acid extracts.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at -20ºC from date of receipt.
Packaging Information
Material Size 500 µg
Transport Information
Supplemental Information
Specifications

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