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Anti-c-Jun (C-term), clone EP693Y

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货号：04-210

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB M Purified Monoclonal Antibody
Description
Catalogue Number MAB3732
Replaces 04-210
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-c-jun Antibody, clone 6A6.2
Alternate Names
  • Activator Protein 1
  • AP-1
Background Information c-Jun is a component of the transcription factor AP-1 that binds and activates transcription at TRE/AP-1 elements and appears to be a major downstream target of the SAPK/JNK signaling pathway. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73. Extracellular signals including growth factors, transforming oncoproteins and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun dependent transcription. Mutation of Ser63/73 renders c-Jun nonresponsive to mitogenic and stress induced signaling pathways. The MAP kinase homologue, SAPK/JNK, binds to the N-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73. In addition, the activity of SAPK/JNK is stimulated by the same signals that activate c-Jun.
References
Product Information
Format Purified
Control
  • NIH-3T3 cells
Presentation Protein A purified immunoglobulin. Liquid in 0.02M phosphate buffer, 0.25M NaCl, pH 7.6, with 0.1% sodium azide
Applications
Application Use Anti-c-jun Antibody, clone 6A6.2 (Mouse Monoclonal Antibody) validated in WB to detect c-jun also known as JNK1 alpha protein kinase, JNK1 beta protein kinase.
Key Applications
  • Western Blotting
Application Notes Western blot: (1-2 ug/mL)

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Recombinant c-Jun GST fusion protein
Clone 6A6.2
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity Recognizes c-Jun, the cellular homolog of the avian sarcoma virus 17 oncogene, v-jun. It is a member of the transcriptional complex called AP1, a group of related dimeric basic region-leucine zipper proteins belonging to the Jun, Fos, Maf, and ATF subfamilies. c-Jun is activated by phosphorylation by c-Jun-N-terminal kinases (JNKs).
Isotype IgG2a
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.
Gene Symbol
  • JUN
  • AP1
  • p39
  • c-Jun
UniProt Number
UniProt Summary FUNCTION: SwissProt: P05412 # Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.
SIZE: 331 amino acids; 35676 Da
SUBUNIT: Interacts with FOS to form a dimer. Interacts with SMAD3/SMAD4 heterodimers. Interacts with MYBBP1A, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.
SUBCELLULAR LOCATION: Nucleus.
PTM: Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC.
SIMILARITY: SwissProt: P05412 ## Belongs to the bZIP family. Jun subfamily. & Contains 1 bZIP domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at 2-8°C in undiluted aliquots for up to 12 months.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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