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PIP5-Kinase HTRF Assay (384 wells)

市场价：
35.00
促销价：
¥0.00

货号：33-125

品牌：Millipore 密理博

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Replacement Information
Description
Catalogue Number 33-125
Brand Family Upstate
Trade Name
  • HTRF
  • Upstate
Description PIP5-Kinase HTRF Assay
References
Product Information
Components
  • Reaction Buffer (4X)
  • DM A Detection Reagent
  • DM C Detection Reagent
  • DM E Detection Reagent
  • Phosphatidylinositol 4-phosphate (1mM)
  • Phosphatidylserine (1mM)
  • Stop Reagent D
Detection method HTRF
Applications
Application The PIP5 Kinase HTRF Assay kit provides a method for assaying PI(4)P-5 kinases in a homogenous 384 well format. Suitable for screening of potential inhibitors of these enzymes.
Key Applications
  • Kinase Assay
Biological Information
Species Reactivity
  • Human
  • Mouse
Analytes Available
  • PIP5 Kinase
Entrez Gene Number
Entrez Gene Summary Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs.
Gene Symbol
  • PIP5K1α
  • PIP5K1γ
Target Sub-Family PI3K/PI4K
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 12 months at -70°C
Packaging Information
Material Size 384 wells
Material Package Kit capacity: 384 wells
Transport Information
Supplemental Information
Specifications

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