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Anti-EEA1 (rabbit polyclonal)

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货号：07-1820

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M WB, ICC Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number 07-1820
Description Anti-EEA1 Antibody
Alternate Names
  • early endosome antigen 1
  • early endosome-associated protein
  • early endosome antigen 1, 162kD
  • Endosome-associated protein p162
  • Zinc finger FYVE domain-containing protein 2
Background Information Early endosome antigen 1 (EEA1) is a 170 kDa coiled-coil protein belonging to a group of early endosomal Rab5 effector proteins. EEA1 has a putative role in the tethering/docking of endocytic vesicles prior to their fusion with early endosomes. This protein is characterized as containing a zinc finger-like domain and coiled-coil regions. The zinc finger-like domain, also known as the FYVE finger, is a motif rich in cystine, is a necessary component of EEA1’s ability for endosomal targeting, and is specifically known for its dual interaction with Rab5 GTPase and phosphotidylinositol 3-phosphate (Ptdlns-3-P).
References
Product Information
Format Affinity Purified
Control
  • BALB 3T3/A31 cell lysate
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Applications
Application This Anti-EEA1 Antibody is validated for use in WB, IC for the detection of EEA1.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application Notes Western Blot (SNAP ID) Analysis: 1:250 dilution from a previous lot detected EEA1 on 10 µg of C2C12 cell lysate.

Immunocytochemistry Analysis: 1:500 dilution from a previous lot detected EEA1 in HeLa, A431, and C2C12 cells.
Biological Information
Immunogen GST-tagged recombinant protein corresponding to the C-terminus of human EEA1.
Epitope C-terminus
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes EEA1.
Species Reactivity
  • Human
  • Mouse
Species Reactivity Note Demonstrated to react with Human and Mouse.
Equine and Canine (99% sequence homology). Rat (98% sequence homology). Bovine (97% sequence homology).
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • EEA1
  • ZFYVE2
  • MST105
  • MSTP105
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.

SUBUNIT STRUCTURE: Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding.

SUBCELLULAR LOCATION: Cytoplasm. Early endosome membrane; Peripheral membrane protein.

DOMAIN: The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate.

MISCELLANEOUS: Antibodies against EEA1 are found in sera from patients with subacute cutaneous lupus erythematosus and other autoimmune diseases.

SEQUENCE SIMILARITIES: Contains 1 C2H2-type zinc finger.

Contains 1 FYVE-type zinc finger.
Molecular Weight ~ 170 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in BALB 3T3/A31 cell lysate.

Western Blot Analysis: A 1:1000 dilution of this antibody detected EEA1 on 10 µg of BALB 3T3/A31 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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