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Anti-E2F-6, clone LL6-2 (mouse monoclonal)

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货号：MABE57

品牌：Millipore 密理博

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Replacement Information

特卖

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB M Purified Monoclonal Antibody
Description
Catalogue Number MABN711
Replaces MABE517
Description Anti-PAX5 Antibody, clone 7D3
Alternate Names
  • Paired box protein Pax-5
  • B-cell-specific transcription factor
  • BSAP
Background Information Paired box protein Pax-5, (PAX5) or B-cell-specific transcription factor (BSAP), is an important transcription factor in the maturation B-cells as well in the regulation of CD19, another B cell specific marker. PAX5 also appears to play a similar role in neural development and spermatogenesis. Its expression is developmentally regulated being expressed primarily only during early development and limited to the nucleus. As with many transcription factors, PAX5 has multiple isoforms at the protein level but they appear all function similarly. As a member of the paired box (PAX) family of transcription factors, it contains the central feature of this gene family, the unique and highly conserved DNA-binding motif known as the paired box. The PAX proteins are important regulators in early development, and alterations in the expression of their genes play important roles in neoplastic transformation and cancer. Mutations and abnormal expression of PAX5 have been associated in many cancers as well unusual diseases. For instance, the Reed-Sternberg cells of Hodgkin’s lymphoma (a classic cell type identified in the disease) almost always express Pax-5, and a chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia. EMD-Millipore’s mouse anti-PAX5 monoclonal, clone 7D3/1A7 has been tested in western blot against recombinant human PAX-5 protein as well as Raji lymphoblastoid cell lysates and human umbilical vein endothelial cell line EVC-304 cell lysates. The clone has also been tested against purified recombinant protein in ELISA.
References
Product Information
Format Purified
Control
  • Raji cell lysate
Presentation Purified mouse monoclonal in PBS containing up to 0.1% sodium azide and 0.05% protein stabilizer.
Applications
Application Detect PAX5 using this mouse monoclonal antibody, Anti-PAX5 Antibody & clone 7D3 validated for use in western blotting.
Key Applications
  • Western Blotting
Application Notes Immunohistochemistry Analysis: A 1:500-1,000 dilution from a representative lot detected PAX5 in human tonsil tissue.

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Purified recombinant fragment of human PAX5 expressed in E. Coli.
Clone 7D3
Host Mouse
Isotype IgG1
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Gene Symbol
  • PAX5
Purification Method Purified
UniProt Number
Molecular Weight ~45 kDa observed. Uniprot describes 6 isoforms between ~32 kDa and ~42 kDa.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blotting in human PAX5 recombinant protein.

Western Blotting Analysis: A 1:2,000 dilution of this antibody detected PAX5 in Raji cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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