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Anti-Gemin5, clone 10G11 (mouse monoclonal)

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货号：05-1535

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, ICC M Purified Monoclonal Antibody
Description
Catalogue Number 05-1535
Description Anti-Gemin5 Antibody, clone 10G11
Alternate Names
  • gem (nuclear organelle) associated protein 5
Background Information Gemin5 is the snRNA-binding component of the SMN complex. The survival of motor neurons (SMN) complex is essential for the biogenesis of small nuclear ribonucleoprotein (snRNP) complexes in eukaryotic cells. Reduced levels of SMN cause the motor neuron degenerative disease, spinal muscular atrophy. As part of this complex, Gemin5 is found in the cytoplasm, nucleoli, and in nuclear bodies called Gemini bodies (gems). Gemin5-containing subunits bind small nuclear RNA independently of the SMN complex and without a requirement for exogenous ATP. ATP hydrolysis is, however, required for displacement of small nuclear RNAs from the Gemin5-containing subunits and their assembly into snRNPs.
References
Product Information
Format Purified
Control
  • K562 cell lysate
Presentation Purified Mouse Monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-Gemin5 Antibody, clone 10G11 is a Mouse Monoclonal Antibody for detection of Gemin5 also known as gem (nuclear organelle) associated protein 5 & has been validated in WB, ICC.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application Notes Immunocytochemistry:
A representative lot of this antibody was used by an independent laboratory for immunocytochemistry analysis. See Feng, W., et al. (2005). Hum. Mol. Genet. 14: 1605 - 1611.
Biological Information
Immunogen Histidine-tagged recombinant protein corresponding to human Gemin5.
Epitope Unknown
Clone 10G11
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity This antibody recognizes Gemin5.
Isotype IgG2aκ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary GEMIN5 is part of a large macromolecular complex localized to both the cytoplasm and the nucleus that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), and GEMIN4 (MIM 606969).[supplied by OMIM].
Gene Symbol
  • gemin 5
  • gemin5
  • GEMIN5
  • MGC142174
  • DKFZp586M1824
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. GEMIN5 acts as the snRNA-binding protein of the SMN complex.

SUBUNIT STRUCTURE: Part of the core SMN complex that contains SMN1, SIP1/GEMIN2, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Interacts directly with SMN1, SNRPB, SNRPD1, SNRPD2, SNRPD3 and SNRPE.

SUBCELLULAR LOCATION: Nucleus › nucleoplasm. Nucleus › gem. Cytoplasm. Note: Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.

SEQUENCE SIMILARITIES: Belongs to the WD repeat gemin-5 family.

Contains 13 WD repeats.
Molecular Weight ~ 169 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in K562 cell lysate.

Western Blot Analysis: 0.1 µg/mL of this antibody detected Gemin5 on 10 µg of K562 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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